- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CGA Antibody Recombinant Rabbit mAb / CHGA / Chromogranin A [clone CHGA/8929R] (V4365)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4365-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V4365-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
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V4365SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | CHGA/8929R |
| Purity | Protein A/G affinity |
| UniProt | P10645 |
| Localization | Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT |
| Limitations | This CGA antibody is available for research use only. |
|
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CGA antibody recognizes Chromogranin A, a secretory granule glycoprotein encoded by the CHGA gene and a hallmark marker of neuroendocrine differentiation. CGA Antibody Recombinant Rabbit MAb (clone CHGA/8929R) is designed to detect Chromogranin A in research applications evaluating endocrine and neuroendocrine tissues. Chromogranin A localizes predominantly to the cytoplasm within dense-core secretory granules, where it participates in hormone packaging, granule biogenesis, and regulated secretion.
CGA antibody, also referred to as Chromogranin A antibody and CgA antibody in the literature, targets a member of the granin family of acidic secretory proteins. Chromogranin A is synthesized as a precursor protein that undergoes proteolytic processing to generate biologically active peptides including vasostatin, pancreastatin, and catestatin. These peptides contribute to modulation of cardiovascular tone, metabolic signaling, and neuroendocrine communication. Within the trans-Golgi network and secretory vesicles, Chromogranin A promotes aggregation of peptide hormones and supports formation of stable secretory granules.
CHGA expression is characteristic of adrenal medulla chromaffin cells, pancreatic islet cells, gastrointestinal enteroendocrine cells, parathyroid tissue, and dispersed neuroendocrine cells across multiple organ systems. The expected staining pattern is cytoplasmic granular positivity reflecting localization within secretory vesicles. Because of this restricted lineage distribution, Chromogranin A is widely used in research to identify neuroendocrine cells and to study differentiation pathways in normal and neoplastic tissues.
In tumor biology investigations, Chromogranin A expression is commonly evaluated in neuroendocrine neoplasms such as carcinoid tumors, pancreatic neuroendocrine tumors, small cell carcinoma, medullary thyroid carcinoma, and pheochromocytoma. Strong cytoplasmic staining supports neuroendocrine lineage, whereas most non-neuroendocrine carcinomas demonstrate limited or absent expression. CGA Antibody Recombinant Rabbit MAb (clone CHGA/8929R) provides consistent detection of Chromogranin A expression patterns in research settings.
This recombinant rabbit monoclonal antibody is generated by expression in mammalian cells to enhance lot-to-lot reproducibility and performance consistency for research use at NSJ Bioreagents.
Optimal dilution of the CGA antibody recombinant rabbit mAb should be determined by the researcher.
Recombinant full-length human protein was used as the immunogen for the CGA antibody recombinant rabbit mAb.
Aliquot the CGA antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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