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Home >> Antibodies >> CFTR Antibody / Cystic Fibrosis Transmembrane Regulator

CFTR Antibody / Cystic Fibrosis Transmembrane Regulator [clone M3A7] (V7667)

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  Catalog No Formulation Size Price (USD)  
Image V7667-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V7667-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V7667SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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IHC testing of FFPE human pancreas with CFTR antibody (clone M3A7). Staining of FFPE tissue is enhanced by boiling tissue sections in 10mM Tris with 1mM EDTA, pH9 for 10-20 min followed by cooling at RT for 20 min.
IHC testing of FFPE human pancreas with CFTR antibody (clone M3A7). Staining of FFPE tissue is enhanced by boiling tissue sections in 10mM Tris with 1mM EDTA, pH9 for 10-20 min followed by cooling at RT for 20 min.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name M3A7
Purity Protein G affinity chromatography
UniProt P13569
Localization Cell surface, cytoplasmic
Applications Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This CFTR antibody is available for research use only.
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Description

CFTR is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3',5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.

Application Notes

Optimal dilution of the CFTR antibody should be determined by the researcher.

Immunogen

Human recombinant protein was used as the immunogen for this CFTR antibody.

Storage

Store the CFTR antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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