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Home >> Antibodies >> CEA Antibody / Carcinoembryonic Antigen

CEA Antibody / Carcinoembryonic Antigen [clone C66/1009] (V2376CF488)

  Catalog No Formulation Size Price (USD)  
Image V2376CF488-100T 500 ul at 0.1 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 Tests 519
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Availability 1-3 business days
Species Reactivity Human
Format CF488 Conjugate
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2a, kappa
Clone Name C66/1009
Purity Protein G affinity chromatography
UniProt P06731
Localization Cytoplasmic and luminal surface
Applications Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This CEA antibody is available for research use only.
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Description

This antibody recognizes proteins of 80-200kDa, identified as different members of CEA family. CEA is synthesized during development in the fetal gut and is re-expressed in increased amounts in intestinal carcinomas and several other tumors. This MAb does not react with nonspecific cross-reacting antigen (NCA) and with human polymorphonuclear leucocytes. It shows no reaction with a variety of normal tissues and is suitable for staining of formalin/paraffin tissues. CEA is not found in benign glands, stroma, or malignant prostatic cells. Antibody to CEA is useful in detecting early foci of gastric carcinoma and in distinguishing pulmonary adenocarcinomas (60-70% are CEA+) from pleural mesotheliomas (rarely or weakly CEA+). Anti-CEA positivity is seen in adenocarcinomas from the lung, colon, stomach, esophagus, pancreas, gallbadder, urachus, salivary gland, ovary, and endocervix.

Application Notes

Optimal dilution of the CEA antibody should be determined by the researcher.

Immunogen

Human full-length recombinant CEA protein was used as the immunogen for this antibody.

Storage

Store the CEA antibody at 2-8oC, protected from light.

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