- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CDX2 Antibody [clone CDX2/1690] (V3415)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V3415-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 539 | |
|
|
V3415-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 249 | |
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V3415SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 539 |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2a, kappa |
| Clone Name | CDX2/1690 |
| Purity | Protein G affinity chromatography |
| Buffer | 1X PBS, pH 7.4 |
| UniProt | Q99626 |
| Localization | Nuclear |
| Applications | ELISA : 2-4ug/ml (order BSA/azide-free format) Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This CDX2 antibody is available for research use only. |
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CDX2 antibody is an established reagent for studying caudal type homeobox 2, a transcription factor that regulates intestinal development and differentiation. CDX2 is expressed primarily in the nuclei of epithelial cells lining the small and large intestines. It directs gene expression programs that define intestinal identity, maintain epithelial renewal, and support proper absorptive and secretory functions. Because of its restricted expression pattern, CDX2 has become a valuable marker in developmental biology and diagnostic pathology.
CDX2 functions as a transcription factor with a homeobox DNA binding domain. It regulates genes involved in enterocyte differentiation, mucin production, and cell polarity. During development, CDX2 ensures the proper specification of intestinal tissue from endodermal precursors. In the adult intestine, it maintains epithelial turnover and contributes to barrier integrity. Altered CDX2 expression has been linked to disease, including colorectal cancer and gastric metaplasia.
The CDX2 antibody clone CDX2/1690 provides specific recognition of this transcription factor. Clone CDX2/1690 has been widely adopted in pathology for distinguishing colorectal adenocarcinoma from other tumor types. Its nuclear staining pattern in intestinal epithelial cells offers diagnostic clarity in identifying tumors of gastrointestinal origin. In basic research, the antibody is applied to studies of intestinal development, epithelial renewal, and tumor biology.
Loss or reduction of CDX2 expression is associated with poor prognosis in colorectal cancer, highlighting its role as both a biomarker and a functional regulator. Research using clone CDX2/1690 has clarified how CDX2 expression influences tumor differentiation, invasion, and patient outcomes. The protein also informs regenerative medicine studies, where modulation of CDX2 may aid in directing stem cell differentiation toward intestinal lineages.
NSJ Bioreagents provides this CDX2 antibody to support investigations in developmental biology, oncology, and gastrointestinal pathology. Alternate names for this protein include caudal type homeobox transcription factor 2 antibody, intestinal specific transcription factor antibody, CDX homeobox protein antibody, and intestinal epithelium transcription regulator antibody. These reflect the varied terminology used across different fields.
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the CDX2 antibody to be titered up or down for optimal performance.
Amino acids 150-249 from the human protein were used as the immunogen for this CDX2 antibody.
Store the CDX2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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