- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CDT1 Antibody / Chromatin Licensing and DNA Replication Factor 1 (R33167)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
R33167-100UG | 0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide | 100 ug | 475 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Antigen affinity purified |
| Host | Goat |
| Clonality | Polyclonal (goat origin) |
| Isotype | Goat Ig |
| Purity | Antigen affinity |
| Gene ID | 81620 |
| Applications | Western Blot : 1-3ug/ml ELISA (peptide) LOD : 1:64000 |
| Limitations | This CDT1 antibody is available for research use only. |
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CDT1 Antibody is designed for the detection and study of CDT1 (Chromatin Licensing and DNA Replication Factor 1), a critical regulator of DNA replication that ensures accurate duplication of the genome during cell division. CDT1 functions during the G1 phase of the cell cycle by licensing replication origins prior to DNA synthesis, allowing chromosomal DNA to be replicated once and only once during each cell cycle. Because precise control of genome duplication is essential for cellular viability and genomic integrity, CDT1 serves as a key component of the molecular machinery governing cell proliferation and chromosome maintenance.
CDT1 plays a central role in assembly of the pre-replication complex through recruitment and loading of the MCM helicase complex onto replication origins. This licensing process establishes replication competence before entry into S phase and is tightly regulated to prevent inappropriate re-replication of DNA. Multiple cellular pathways control CDT1 abundance and activity throughout the cell cycle, ensuring that replication origins fire correctly and that genomic stability is maintained.
Expression of CDT1 is closely associated with actively proliferating cells and is frequently examined in studies of cell cycle progression, developmental biology, stem cell function, tissue growth, and regenerative processes. Because DNA replication licensing is required for cellular expansion and normal tissue maintenance, CDT1 has become an important marker for investigating mechanisms that regulate proliferation and cell cycle control in both normal and diseased tissues.
Disruption of CDT1 regulation can contribute to replication stress, chromosome instability, DNA damage accumulation, and abnormal cell cycle progression. Consequently, CDT1 remains an important target in research involving cancer biology, genome maintenance pathways, DNA damage responses, and cellular checkpoint mechanisms. Studies of CDT1 continue to provide valuable insight into how cells preserve genomic integrity while supporting growth, development, and tissue homeostasis.
CDT1 Antibody is widely used to investigate DNA replication licensing pathways, cell cycle regulation, and molecular mechanisms controlling genome duplication. Researchers utilize CDT1 Antibody reagents to evaluate protein expression patterns and study biologic processes involved in cellular proliferation, chromosome maintenance, developmental regulation, and genome stability.
Learn more about CDT1 and related DNA replication control pathways on our CDT1 Antibody / DNA Replication Licensing Factor Antibody page.
Optimal dilution of the CDT1 antibody should be determined by the researcher.
Amino acids ARLAHQTRAEEGL were used as the immunogen for this CDT1 antibody.
Aliquot and store the CDT1 antibody at -20oC.
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