- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CDKN1B Antibody / Cyclin-dependent kinase inhibitor 1B / p27Kip1 [clone r1B4] (V5850)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V5850-100UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 100 ug | 559 | |
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V5850-20UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 20 ug | 259 | |
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V5850SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG2a, kappa |
| Clone Name | r1B4 |
| UniProt | P46527 |
| Localization | Endosome, Nucleus |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml Western Blot : 2-4ug/ml |
| Limitations | This CDKN1B/Cyclin-dependent kinase inhibitor 1B antibody is available for research use only. |
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CDKN1B antibody targets Cyclin-dependent kinase inhibitor 1B, also called p27, KIP1 and p27Kip1, a key cell cycle regulatory protein encoded by the CDKN1B gene. Cyclin-dependent kinase inhibitor 1B is commonly known as p27 Kip1 and functions as a negative regulator of cyclin-CDK complexes, particularly those controlling the G1 to S phase transition. CDKN1B is predominantly localized to the nucleus, where it regulates cell cycle progression by inhibiting cyclin E-CDK2 and cyclin A-CDK2 activity.
As a member of the CIP/KIP family of cyclin-dependent kinase inhibitors, Cyclin-dependent kinase inhibitor 1B plays a critical role in maintaining cell cycle checkpoints and controlling cellular proliferation. CDKN1B antibody, also referred to as p27 Kip1 antibody in the literature, is widely used to study mechanisms of cell cycle arrest, differentiation, and quiescence. In addition to its nuclear functions, p27 Kip1 has been reported to exhibit cytoplasmic localization under certain biological conditions, where it may participate in cytoskeletal regulation and cell motility.
Expression of CDKN1B is tightly regulated at multiple levels, including transcription, phosphorylation, ubiquitin-mediated degradation, and subcellular localization. CDKN1B antibody is therefore useful for examining regulatory pathways that influence protein stability and intracellular distribution. Altered expression or mislocalization of Cyclin-dependent kinase inhibitor 1B has been associated with dysregulated cell proliferation and loss of growth control in disease-related research contexts.
In cancer biology, CDKN1B is frequently investigated as a tumor suppressor protein. Reduced nuclear expression of p27 Kip1 has been correlated with increased proliferative activity and adverse clinical features in multiple tumor types. CDKN1B antibody is commonly applied in studies focused on tumor classification, cell cycle dysregulation, and therapeutic response mechanisms.
This CDKN1B antibody, clone r1B4, is designed to recognize Cyclin-dependent kinase inhibitor 1B in research applications. Clone r1B4 supports detection of CDKN1B/p27Kip1 expression and localization and is suitable for studies examining cell cycle regulation, proliferation control, and CDK inhibitor signaling pathways.
1. Optimal dilution of the CDKN1B/Cyclin-dependent kinase inhibitor 1B antibody should be determined by the researcher.
2. This CDKN1B/Cyclin-dependent kinase inhibitor 1B antibody is recombinantly produced by expression in CHO cells.
Prokaryotic recombinant antigen corresponding to the full length p27 molecule was used as the immunogen for the CDKN1B/Cyclin-dependent kinase inhibitor 1B antibody.
CDKN1B/Cyclin-dependent kinase inhibitor 1B antibody with sodium azide - store at 2 to 8oC; antibody without sodium azide - store at -20 to -80oC.
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