- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CDH3 Antibody Clone 12H6 / Cadherin 3 Monoclonal Antibody [clone 12H6] (V3329)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V3329-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V3329-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V3329SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
|
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | 12H6 |
| Purity | Protein G affinity chromatography |
| Buffer | 1X PBS, pH 7.4 |
| UniProt | P22223 |
| Localization | Cell surface, cytoplasmic |
| Applications | Flow Cytometry : 0.5-1ug/10^6 cells Immunofluorescence : 1-2ug/ml Western Blot : 0.5-1ug/ml |
| Limitations | This CDH3 Antibody Clone 12H6 / Cadherin 3 Monoclonal Antibody is available for research use only. |
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CDH3 Antibody Clone 12H6 / Cadherin 3 Monoclonal Antibody detects the epithelial adhesion protein encoded by the CDH3 gene. Clone 12H6 is a monoclonal antibody developed for the detection of Cadherin 3, also known as P-Cadherin or placental cadherin. CDH3 is a member of the classical cadherin family of calcium-dependent transmembrane proteins that regulate cell-cell adhesion and epithelial organization. Through extracellular cadherin repeat domains and intracellular connections with catenin-associated pathways, Cadherin 3 helps maintain tissue structure, cell junction formation and communication between neighboring epithelial cells.
CDH3 Antibody Clone 12H6 / Cadherin 3 Monoclonal Antibody provides researchers with a clone-specific reagent for evaluating Cadherin 3 expression and localization. Monoclonal antibodies recognize defined target regions, supporting consistent detection in studies involving epithelial markers and adhesion-related pathways. CDH3 expression is commonly examined in models of epithelial differentiation, cellular organization and changes in cell adhesion associated with normal development or disease processes.
Cadherin 3 has been extensively studied in cancer research due to altered expression patterns reported in several malignancies. Increased CDH3 expression has been investigated in breast cancer, ovarian cancer, pancreatic cancer and additional tumor types, where changes in adhesion signaling may influence tumor cell behavior, invasion and interactions with the surrounding microenvironment. Detection of CDH3 protein expression helps researchers evaluate epithelial remodeling, tumor phenotype and pathways connecting adhesion molecules with cancer progression.
Beyond its role as a cancer-associated marker, Cadherin 3 is important for understanding epithelial biology and tissue development. The protein is associated with basal epithelial compartments and contributes to processes that regulate cell positioning, differentiation and maintenance of organized tissue structures. Genetic alterations involving CDH3 have also been connected with developmental disorders affecting specialized tissues, further demonstrating the importance of proper cadherin-mediated adhesion.
NSJ Bioreagents offers CDH3 Antibody Clone 12H6 / Cadherin 3 Monoclonal Antibody for researchers studying cadherin proteins, epithelial cell adhesion and cancer biology pathways. This antibody supports analysis of CDH3 expression, localization and function in relevant research applications. CDH3 Antibody Clone 12H6 / Cadherin 3 Monoclonal Antibody provides a reliable tool for investigating Cadherin 3 biology, cell junction regulation and mechanisms controlling epithelial cell communication.
Researchers studying CDH3 expression and cadherin family signaling may also be interested in our P-Cadherin Antibody / Epithelial Cell Adhesion Antibody page, which highlights epithelial junction regulation, cell-cell adhesion and tissue organization pathways.
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the CDH3 Antibody Clone 12H6 / Cadherin 3 Monoclonal Antibody to be titered up or down for optimal performance.
A human full length recombinant protein was used as the immunogen for this P-Cadherin / CDH3 antibody.
Store the CDH3 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
P-Cadherin antibody, Cadherin 3 antibody, Placental Cadherin antibody, CDH3 Monoclonal antibody, CDHP antibody, HJMD antibody, Cadherin Family Member 3 antibody
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