- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CDH2 Antibody 8C11 / N-Cadherin [clone 8C11] (V3391)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V3391-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
|
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V3391-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
|
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V3391SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Species Reactivity | Human, Mouse |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | 8C11 |
| Purity | Protein G affinity chromatography |
| Buffer | 1X PBS, pH 7.4 |
| UniProt | P19022 |
| Localization | Cell surface, cytoplasmic |
| Applications | Flow Cytometry : 1-2ug/million cells Immunofluorescence : 1-3ug/ml Western Blot : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This CDH2 Antibody 8C11 is available for research use only. |
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CDH2 Antibody 8C11 / N-Cadherin is a mouse monoclonal antibody recognizing Cadherin 2, a calcium-dependent cell adhesion protein encoded by the CDH2 gene. Commonly known as N-Cadherin and CD325, CDH2 is a classical cadherin that mediates homophilic interactions between neighboring cells and contributes to the formation and maintenance of adherens junctions. N-Cadherin contains extracellular cadherin domains, a transmembrane region, and a cytoplasmic domain that interacts with catenins and the actin cytoskeleton. These molecular interactions connect cell-cell adhesion with cytoskeletal organization and intracellular signaling.
N-Cadherin is prominently expressed in neural, cardiac, and mesenchymal tissues and has important functions during embryonic development. In the nervous system, CDH2 participates in neuronal migration, neurite development, axon guidance, synapse formation, and synaptic organization. In cardiac tissue, N-Cadherin is an important component of intercalated discs and contributes to mechanical coupling and structural organization between cardiomyocytes. A CDH2 Antibody can therefore support research into cell-cell junctions, neural development, cardiac biology, tissue morphogenesis, and mechanisms regulating cellular adhesion.
CDH2 is also extensively investigated in epithelial-mesenchymal transition and cancer progression. Increased N-Cadherin expression frequently accompanies the transition from an epithelial toward a more motile mesenchymal phenotype, often in association with reduced E-Cadherin expression. This phenomenon, commonly referred to as cadherin switching, is studied in relation to tumor cell migration, invasion, metastatic potential, and altered interactions with surrounding cells. N-Cadherin is consequently an important target in research examining EMT, tumor progression, cellular differentiation, and adhesion-associated signaling. CDH2 Antibody clone 8C11 has been used extensively in published research across these and other areas of cell biology.
Clone 8C11 recognizes an extracellular region of N-Cadherin and has a long history as a research reagent. Independent commercial literature databases currently associate the clone with dozens of scientific publications, supporting its established use in CDH2 research. NSJ Bioreagents offers clone 8C11, a mouse monoclonal antibody, for investigating N-Cadherin expression and localization. This CDH2 Antibody clone provides a well-established reagent with numerous published research uses for studies of N-Cadherin, cell-cell adhesion, adherens junctions, EMT, neural and cardiac biology, and cancer.
For additional information on Cadherin 2/N-Cadherin and its roles in cell-cell adhesion, epithelial-mesenchymal transition, and cancer biology, see our Cadherin 2 Antibody / CDH2 page.
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the CDH2 Antibody 8C11 to be titered up or down for optimal performance.
A human partial recombinant protein corresponding to the N-Cadherin extracellular domain was used as the immunogen for this CDH2 Antibody 8C11.
Store the CDH2 Antibody 8C11 at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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