CDH17 Antibody for IHC / Liver intestine cadherin [clone MSVA-517M] (V6058)

Immunohistochemistry of CDH17 antibody in human tissue microarrays. The mouse monoclonal clone MSVA-517M demonstrates strong, predominantly membranous HRP-DAB brown staining in gastrointestinal epithelial cells, particularly within small intestine and colon mucosa, consistent with the known localization of Cadherin 17 along lateral cell membranes. In normal tissues, staining is largely restricted to intestinal-type epithelium, while most non-gastrointestinal organs show minimal to absent signal.
In cancer tissue arrays, membranous CDH17 expression is observed in colorectal adenocarcinoma and other gastrointestinal-derived tumors, supporting its established role as a marker of intestinal differentiation. Many non-intestinal malignancies show weak or negative staining, consistent with published expression profiles. Overall staining patterns correlate with publicly available expression data, including Human Protein Atlas datasets.