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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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CDH17 antibody targets Cadherin 17, also referred to as Liver-intestine cadherin, a calcium-dependent cell adhesion protein encoded by the CDH17 gene. Cadherin 17 is a non-classical member of the cadherin superfamily and is predominantly localized to the cell membrane of epithelial cells lining the gastrointestinal tract. Structurally, Cadherin 17 contains seven extracellular cadherin repeats and a short cytoplasmic domain that lacks a catenin-binding region, distinguishing it from classical cadherins such as E-cadherin.
Cadherin 17 plays an important role in epithelial organization, cell polarity, and maintenance of intestinal tissue architecture. CDH17 antibody, also commonly referred to as LI-cadherin antibody in the literature, is frequently used to investigate adhesion mechanisms in gastrointestinal epithelial cells. The calcium-dependent adhesive properties of Liver-intestine cadherin support stable epithelial cell-cell contacts while allowing dynamic tissue remodeling.
Expression of Cadherin 17 is highest in the small intestine and colon, with limited expression in most non-intestinal tissues. CDH17 antibody is therefore a valuable reagent for studying gastrointestinal epithelial differentiation and lineage specificity. Liver-intestine cadherin expression is well characterized in normal intestinal mucosa and is commonly retained in intestinal-type epithelial tumors, reinforcing its utility as a tissue-specific epithelial marker.
In cancer-related research, altered expression of Cadherin 17 has been associated with tumor progression and metastatic behavior in gastrointestinal malignancies. CDH17 antibody is widely applied as a diagnostic and classification marker for identifying tumors of intestinal origin and for distinguishing gastrointestinal-derived carcinomas from non-intestinal epithelial tumors.
This CDH17 antibody, clone CDH17/8515R, is designed to recognize Cadherin 17 protein in research applications. Clone CDH17/8515R supports detection of membrane-associated CDH17 expression and is suitable for studies focused on epithelial adhesion, gastrointestinal biology, and tumor characterization.
This antibody is part of a broader antibody panel offered by NSJ Bioreagents.
Optimal dilution of the CDH17 antibody rabbit monoclonal should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 242-418) from the human protein was used as the immunogen for the CDH17 antibody rabbit monoclonal.
Aliquot the CDH17 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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