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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CDH17 Antibody Rabbit Monoclonal / Cadherin 17 [clone CDH17/8515R] (V5260)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V5260-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V5260-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V5260SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | CDH17/8515R |
| Purity | Protein A affinity |
| UniProt | Q12864 |
| Localization | Cell Surface, Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT Western Blot : 2-4ug/ml |
| Limitations | This CDH17 antibody is available for research use only. |
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CDH17 antibody targets Cadherin 17, also referred to as Liver-intestine cadherin, a calcium-dependent cell adhesion protein encoded by the CDH17 gene. Cadherin 17 is a non-classical member of the cadherin superfamily and is predominantly localized to the cell membrane of epithelial cells lining the gastrointestinal tract. Structurally, Cadherin 17 contains seven extracellular cadherin repeats and a short cytoplasmic domain that lacks a catenin-binding region, distinguishing it from classical cadherins such as E-cadherin.
Cadherin 17 plays an important role in epithelial organization, cell polarity, and maintenance of intestinal tissue architecture. CDH17 antibody, also commonly referred to as LI-cadherin antibody in the literature, is frequently used to investigate adhesion mechanisms in gastrointestinal epithelial cells. The calcium-dependent adhesive properties of Liver-intestine cadherin support stable epithelial cell-cell contacts while allowing dynamic tissue remodeling.
Expression of Cadherin 17 is highest in the small intestine and colon, with limited expression in most non-intestinal tissues. CDH17 antibody is therefore a valuable reagent for studying gastrointestinal epithelial differentiation and lineage specificity. Liver-intestine cadherin expression is well characterized in normal intestinal mucosa and is commonly retained in intestinal-type epithelial tumors, reinforcing its utility as a tissue-specific epithelial marker.
In cancer-related research, altered expression of Cadherin 17 has been associated with tumor progression and metastatic behavior in gastrointestinal malignancies. CDH17 antibody is widely applied as a diagnostic and classification marker for identifying tumors of intestinal origin and for distinguishing gastrointestinal-derived carcinomas from non-intestinal epithelial tumors.
This CDH17 antibody, clone CDH17/8515R, is designed to recognize Cadherin 17 protein in research applications. Clone CDH17/8515R supports detection of membrane-associated CDH17 expression and is suitable for studies focused on epithelial adhesion, gastrointestinal biology, and tumor characterization.
Optimal dilution of the CDH17 antibody rabbit monoclonal should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 242-418) from the human protein was used as the immunogen for the CDH17 antibody rabbit monoclonal.
Aliquot the CDH17 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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