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Home >> Antibodies >> CD95 Antibody / Fas

CD95 Antibody / Fas [clone rB-R18] (V4116)

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  Catalog No Formulation Size Price (USD)  
Image V4116-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V4116-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V4116SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
Microvalidated Recmousemono
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SDS-PAGE analysis of purified, BSA-free CD95 antibody (clone rB-R18) as confirmation of integrity and purity.
SDS-PAGE analysis of purified, BSA-free CD95 antibody (clone rB-R18) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Recombinant Mouse Monoclonal
Isotype Mouse IgG2a, kappa
Clone Name rB-R18
Purity Protein A/G affinity
UniProt P25445
Localization Cell surface
Applications Flow cytometry : 1-2ug/million cells
Immunofluorescence : 1-2ug/ml
Immunohistochemistry (Frozen) : 1-2ug/ml for 30 minutes at RT
Limitations This CD95 antibody is available for research use only.
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Description

mAb rB-R18 specifically recognizes CD95, also known as Fas, a transmembrane glycoprotein with a MW of 40-45kDa, containing 8kDa of N-glycoside-linked polysaccharide. It is a receptor for TNFSF6/FASLG, a member of the nerve growth factor receptor/tumor necrosis factor superfamily, mediating receptor-triggered apoptosis. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation, which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). CD95 antigen is expressed on the surface of various cell types, preferentially on the CD45RAlow CD45ROhigh subset of memory T lymphocytes.

Application Notes

Optimal dilution of the CD95 antibody should be determined by the researcher.

Immunogen

Recombinant human CD95 protein was used as the immunogen for the CD95 antibody.

Storage

Aliquot the CD95 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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