- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CD95 Antibody / Fas (R30285)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
R30285 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
| Availability | 1-3 business days |
| Species Reactivity | Mouse, Rat |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity |
| Buffer | Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal |
| UniProt | Q63199 |
| Localization | Cytoplasmic, membranous |
| Applications | Western Blot : 0.5-1ug/ml IHC (FFPE) : 0.5-1ug/ml IHC (Frozen) : 0.5-1ug/ml |
| Limitations | This CD95/Fas antibody is available for research use only. |
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CD95 antibody targets Fas cell surface death receptor, a transmembrane protein encoded by the human FAS gene and a member of the tumor necrosis factor receptor superfamily. CD95 is also widely referred to as Fas and Fas receptor in the apoptosis literature, and these names describe the same protein. The term Fas originates from early studies of programmed cell death, while Fas receptor emphasizes its function as a cell surface death receptor that binds Fas ligand (FASLG). Because of this dual usage, researchers commonly search for CD95 antibody, Fas antibody, or Fas receptor antibody when studying apoptosis signaling pathways.
CD95 is a type I membrane protein primarily localized to the plasma membrane, where it mediates extrinsic apoptotic signaling. Upon binding to Fas ligand, CD95 undergoes trimerization and recruits adaptor proteins such as FADD, leading to formation of the death-inducing signaling complex and activation of caspase cascades. This Fas-mediated apoptosis pathway plays a critical role in immune homeostasis, cytotoxic T cell function, and elimination of damaged or transformed cells.
CD95 is highly expressed in activated lymphocytes and various epithelial tissues and is functionally important in immune regulation. Dysregulation of Fas signaling has been implicated in autoimmune disorders, lymphoproliferative syndromes, and tumor immune evasion. In cancer biology, altered CD95 expression and non-apoptotic Fas signaling have been associated with tumor progression and metastasis, making CD95 antibody a valuable tool for studying both apoptotic and non-apoptotic signaling mechanisms.
As TNF receptor superfamily member 6 (TNFRSF6), CD95 contains extracellular cysteine-rich domains characteristic of death receptors and an intracellular death domain essential for downstream signaling. A CD95 antibody is suitable for investigating Fas receptor expression, apoptosis pathways, immune cell regulation, and tumor biology research applications.
The stated application concentrations are suggested starting amounts. Titration of the CD95/Fas antibody may be required due to differences in protocols and secondary/substrate sensitivity.
An amino acid sequence from the N-terminus of rat CD95 (YTDRKHYSDKCRRCAFCDEGHGL) was used as the immunogen for this CD95/Fas antibody.
After reconstitution, the CD95/Fas antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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