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Home >> Antibodies >> Alpha 2 macroglobulin receptor Antibody / CD91 / LRP1

Alpha 2 macroglobulin receptor Antibody / CD91 / LRP1 [clone LRP1/6784] (V4267)

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  Catalog No Formulation Size Price (USD)  
Image V4267-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V4267-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V4267SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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IHC staining of FFPE human lung tissue with Alpha 2 macroglobulin receptor antibody (clone LRP1/6784) Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human lung tissue with Alpha 2 macroglobulin receptor antibody (clone LRP1/6784) Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name LRP1/6784
Purity Protein A/G affinity
UniProt Q07954
Localization Cytoplasm, Nucleus, Cell surface
Applications Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT
Limitations This Alpha 2 macroglobulin receptor antibody is available for research use only.
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Description

Members of the LDL receptor gene family, including LDLR (low density lipoprotein receptor), LEP1 (low density lipoprotein related protein), megalin (also designated GP330), VLDLR (very low density lipoprotein receptor) and apoER2 are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. LRP1, also designated LRP and Alpha-2-Macroglobulin receptor, is an endocytic receptor that mediates the uptake of at least 15 ligands, including Alpha-2-Macroglobulin and apoE. LRP1 is cleaved into a membrane subunit and an extracellular subunit, which remain non-covalently associated. Proper folding and trafficking of LRP1 is facilitated by the receptor-associated protein (RAP), a molecular chaperone. The uptake of all known ligands through LRP1 can be blocked by RAP, which induces a conformational change in the receptor that renders it unable to bind ligands. LRP1, which is expressed in brain, liver and lung, is also implicated in Alzheimer s disease (AD), as the human LRP gene localizes to a potential AD locus on chromosome 12.

Application Notes

Optimal dilution of the Alpha 2 macroglobulin receptor antibody should be determined by the researcher.

Immunogen

A recombinant fragment of human protein was used as the immunogen for the Alpha 2 macroglobulin receptor antibody.

Storage

Aliquot the Alpha 2 macroglobulin receptor antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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