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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CD90 Antibody (RQ5600)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ5600 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 439 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Affinity purified |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | P04216 |
| Applications | Western Blot : 0.5-1ug/ml Immunohistochemistry (FFPE) : 2-5ug/ml Immunofluorescence : 5ug/ml Direct ELISA : 0.1-0.5ug/ml |
| Limitations | This CD90 antibody is available for research use only. |
|
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CD90 antibody detects CD90, also known as Thy-1, a glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein involved in cell adhesion, migration, and signal transduction. The UniProt recommended name is Thy-1 membrane glycoprotein (CD90). CD90 is broadly expressed across multiple cell types, including fibroblasts, neurons, endothelial cells, mesenchymal stem cells, and subsets of T lymphocytes. It serves as a multifunctional modulator of cell communication in both the immune and nervous systems.
Functionally, CD90 antibody identifies a 161-amino-acid glycoprotein that is heavily N-glycosylated and anchored to the outer leaflet of the plasma membrane via a GPI linkage. CD90 interacts with integrins, syndecans, and other adhesion molecules to regulate cellâcell and cellâmatrix interactions. In the immune system, CD90 functions as a co-stimulatory molecule on T cells, influencing activation and cytokine production. In the nervous system, it contributes to neurite outgrowth, synaptic plasticity, and axonal regeneration by mediating neuronâglia and neuronâmatrix signaling. Its broad cellular expression and dynamic regulation make CD90 a key marker in developmental biology and regenerative medicine.
The CD90 gene (THY1) is located on chromosome 11q23.3 in humans and on chromosome 9 in mice. Although originally characterized as a thymocyte differentiation antigen, CD90 has since been identified as a pan-stem cell marker, particularly for mesenchymal stem cells (MSCs) and hematopoietic progenitors. In fibroblasts and stromal cells, CD90 influences proliferation, differentiation, and matrix remodeling. Its expression is modulated by growth factors, cytokines, and mechanical cues, reflecting its roles in tissue repair and fibrosis.
Pathologically, altered CD90 expression is associated with fibrosis, tumorigenesis, and neurodegenerative disease. In cancer, CD90 can function either as a tumor suppressor or promoter depending on tissue context, with elevated levels linked to cancer-associated fibroblasts and tumor cell invasiveness. In fibrotic disease, upregulation of CD90 contributes to myofibroblast differentiation and extracellular matrix accumulation. In the nervous system, loss of CD90 expression correlates with neuronal damage and impaired regenerative capacity. Because of these diverse roles, CD90 is widely studied as both a biomarker and functional regulator of tissue remodeling, stemness, and immune activation.
CD90 antibody is validated for use in relevant research applications to detect Thy-1 expression and study cell adhesion, differentiation, and immune regulation. NSJ Bioreagents provides CD90 antibody reagents optimized for stem cell biology, immunology, oncology, and neuroscience research.
Optimal dilution of the CD90 antibody should be determined by the researcher.
A human recombinant protein (amino acids Q20-H111) was used as the immunogen for the CD90 antibody.
After reconstitution, the CD90 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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