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Home >> Antibodies >> CD7 Antibody Recombinant Mouse mAb

CD7 Antibody Recombinant Mouse mAb [clone rCD7/6972] (V4555)

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  Catalog No Formulation Size Price (USD)  
Image V4555-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 559
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V4555-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 259
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V4555SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 559
Microvalidated Recmousemono
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Immunohistochemistry analysis of CD7 antibody in human tonsil tissue. FFPE human tonsil shows strong membranous HRP-DAB brown staining in lymphoid cells consistent with CD7-positive T lymphocytes, with surrounding areas showing minimal background. The inset image, using PBS in place of primary antibody as a negative control, demonstrates absence of specific staining. Antigen retrieval was performed by boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 20 minutes followed by cooling prior to incubation with CD7 antibody (clone rCD7/6972).
IHC staining of FFPE human lymph node tissue with CD7 antibody (clone rCD7/6972). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free CD7 antibody (clone rCD7/6972) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Host Mouse
Clonality Recombinant Mouse Monoclonal
Isotype Mouse IgG1, kappa
Clone Name rCD7/6972
Purity Protein A/G affinity
UniProt P09564
Localization Cell Surface
Applications Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Limitations This CD7 antibody is available for research use only.
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Description

CD7 antibody, also known as CD7 antigen antibody, recognizes Cluster of Differentiation 7, a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily. CD7 is predominantly expressed on thymocytes, mature T lymphocytes, and natural killer cells, where it localizes to the plasma membrane and functions as a co-stimulatory receptor in immune signaling. CD7 participates in T cell activation, proliferation, and cytokine production, contributing to lymphocyte development and immune regulation. Because of its restricted expression within the T cell lineage, CD7 antibody is widely used in research focused on T cell biology and lymphoid tissue characterization.

The CD7 gene is located on chromosome 17q25.2 and encodes a protein composed of a single extracellular immunoglobulin-like domain, a transmembrane region, and a short cytoplasmic tail involved in intracellular signaling pathways. CD7-mediated interactions influence downstream signaling events that regulate lymphocyte activation and differentiation. CD7 antibody supports studies investigating thymic maturation, peripheral T cell homeostasis, and immune cell communication within secondary lymphoid organs.

CD7 antibody is particularly valuable in research involving hematologic malignancies. CD7 expression is commonly retained in T cell acute lymphoblastic leukemia and many peripheral T cell lymphomas, and aberrant CD7 expression may also be observed in certain myeloid leukemias. Alterations in CD7 expression patterns can provide insight into lineage determination and disease classification in lymphoproliferative disorders. As such, CD7 antibody is an important tool in studies of leukemic transformation and lymphoid neoplasia.

Clone rCD7/6972 is a recombinant mouse monoclonal antibody developed to detect CD7 with high specificity and reproducibility. Recombinant expression ensures defined antibody sequence identity and consistent lot-to-lot performance. A recombinant CD7 antibody mouse monoclonal mAb format provides reliable detection of membrane-associated CD7 and supports consistent results across research applications.

Beyond oncology-related investigations, CD7 antibody is useful in studies of immune reconstitution, transplantation immunology, and autoimmune disease models where T cell subsets are central to pathogenesis. By targeting a surface antigen expressed early during thymocyte development and maintained on mature T cells, clone rCD7/6972 offers a dependable reagent for examining T cell distribution, immune activation, and lymphoid tissue organization in research settings.

Application Notes

Optimal dilution of the CD7 antibody should be determined by the researcher.

Immunogen

A recombinant partial protein sequence (within amino acids 140-240) from the human protein was used as the immunogen for the CD7 antibody.

Storage

Aliquot the CD7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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