- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CD7 Antibody Rabbit Monoclonal [clone CD7/8357R] (V4560)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4560-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
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V4560-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
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V4560SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | CD7/8357R |
| Purity | Protein A/G affinity |
| UniProt | P09564 |
| Localization | Cell Surface |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This CD7 antibody is available for research use only. |
|
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CD7 antibody, also known as CD7 antigen antibody, recognizes Cluster of Differentiation 7, a type I transmembrane glycoprotein of the immunoglobulin superfamily that is predominantly expressed on thymocytes, mature T lymphocytes, and natural killer cells. CD7 is localized to the plasma membrane and functions as a co-stimulatory receptor involved in T cell activation, cytokine production, and immune signaling. It plays an important role in early T cell development within the thymus and remains expressed on most peripheral T cells, making CD7 antibody a valuable tool for studying T lineage biology and immune cell differentiation.
The CD7 gene is located on chromosome 17q25.2 and encodes a protein containing a single extracellular immunoglobulin-like domain, a hydrophobic transmembrane region, and a short cytoplasmic tail involved in intracellular signaling. Through homotypic and heterotypic interactions, CD7 contributes to the modulation of signaling pathways that regulate lymphocyte activation and proliferation. CD7 antibody supports investigations into thymocyte maturation, peripheral T cell homeostasis, and lymphoid tissue organization.
CD7 antibody is frequently used in research related to hematologic malignancies. CD7 expression is commonly retained in T cell acute lymphoblastic leukemia and various peripheral T cell lymphomas, while aberrant expression patterns may be observed in certain myeloid leukemias. Changes in CD7 expression can assist in the characterization of lymphoproliferative disorders and provide insight into lineage origin and disease progression. As a result, CD7 antibody is widely applied in immunophenotypic and translational research settings focused on lymphoid neoplasms.
Clone CD7/8357R is a recombinant rabbit monoclonal antibody designed to detect CD7 with high specificity and reproducibility. Recombinant production ensures defined sequence identity and consistent performance between manufacturing lots compared to traditional hybridoma-derived reagents. A recombinant CD7 antibody rabbit monoclonal format offers strong affinity and reliable detection of membrane-associated CD7 in research applications.
In addition to oncology research, CD7 antibody is relevant in studies of immune reconstitution, transplantation immunology, and autoimmune disease models in which T cell subsets are central to pathogenesis. By targeting a lineage-associated surface antigen expressed early in thymocyte development and maintained on mature T cells, clone CD7/8357R provides a dependable tool for examining immune cell dynamics and T cell-mediated immune responses.
Optimal dilution of the CD7 antibody should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the CD7 antibody.
Aliquot the CD7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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