- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CD7 Antibody Recombinant Rabbit mAb [clone CD7/3868R] (V4564)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V4564-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V4564-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V4564SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | CD7/3868R |
| Purity | Protein A/G affinity |
| UniProt | P09564 |
| Localization | Cell Surface |
| Applications | Western Blot : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This CD7 antibody is available for research use only. |
|
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CD7 antibody, also known as CD7 antigen antibody, recognizes Cluster of Differentiation 7, a transmembrane glycoprotein expressed predominantly on thymocytes and mature T lymphocytes. CD7 is a member of the immunoglobulin superfamily and functions as a co-stimulatory receptor involved in T cell activation and immune regulation. It is primarily localized to the plasma membrane and is highly expressed in T cell lineage cells, with additional expression reported in natural killer cells and early lymphoid progenitors. CD7 plays an important role in T cell interactions, cytokine production, and signal transduction during immune responses.
The CD7 gene is located on chromosome 17q25.2 and encodes a type I transmembrane protein containing an extracellular immunoglobulin-like domain, a transmembrane segment, and a short cytoplasmic tail. Through its extracellular domain, CD7 participates in cell-cell interactions and modulates signaling pathways that influence lymphocyte proliferation and differentiation. CD7 antibody is commonly used in research focused on T cell development, thymic maturation, and lymphoid malignancies due to the protein's restricted lineage expression.
CD7 antibody is widely utilized in studies of hematologic cancers, particularly T cell acute lymphoblastic leukemia and certain peripheral T cell lymphomas, where CD7 expression is frequently retained. Altered or aberrant expression patterns of CD7 can provide insight into disease classification and cellular origin in lymphoproliferative disorders. In addition, loss of CD7 expression in some T cell neoplasms has diagnostic significance, highlighting the value of a well-characterized CD7 antibody in immunophenotypic analysis.
Clone CD7/3868R is a recombinant rabbit monoclonal antibody designed to target CD7 with high specificity and consistency. Recombinant production ensures defined sequence identity and lot-to-lot reproducibility compared to traditional hybridoma-derived antibodies. A CD7 antibody recombinant rabbit mAb such as clone CD7/3868R supports research applications investigating T cell biology, immune signaling pathways, and lymphoid tissue organization. Its strong membrane-associated staining pattern in CD7-positive cells makes it suitable for detecting CD7 expression in diverse experimental settings.
Beyond oncology research, CD7 antibody is also relevant in studies of immune reconstitution, transplantation biology, and autoimmune conditions where T cell subsets are central to pathogenesis. Because CD7 is expressed early during thymocyte development and persists on most mature T cells, it serves as a useful marker for tracking T cell lineage commitment and immune cell dynamics. The recombinant rabbit monoclonal format of clone CD7/3868R provides a reliable tool for consistent detection of CD7 in research applications.
Optimal dilution of the CD7 antibody should be determined by the researcher.
Recombinant full-length human CD7 protein was used as the immunogen for the CD7 antibody.
Aliquot the CD7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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