- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CD64 Antibody / High-Affinity Fc Gamma Receptor [clone 10.1] (V7768)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V7768-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
|
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V7768-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V7768SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | 10.1 |
| Purity | Protein G affinity chromatography |
| UniProt | P12314 |
| Applications | Flow Cytometry : 1-2ug/million cells |
| Limitations | This CD64 Antibody / High-Affinity Fc Gamma Receptor is available for research use only. |
|
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Fc gamma receptor 1A (FCGR1A), commonly known as CD64, is a high-affinity immunoglobulin gamma Fc receptor encoded by the FCGR1A gene and expressed primarily on monocytes, macrophages, activated neutrophils, and antigen-presenting immune cells. CD64 Antibody / High-Affinity Fc Gamma Receptor is useful for studying innate immune signaling, Fc receptor biology, phagocytosis, inflammatory activation, and leukocyte immunophenotyping. CD64 belongs to the Fc gamma receptor family responsible for binding IgG antibodies and mediating antibody-dependent immune responses.
CD64 antibody, also referred to as FCGR1A antibody, Fc gamma receptor 1A antibody, or Fc gamma RI antibody in the literature, recognizes a transmembrane receptor with exceptionally high affinity for monomeric IgG. Following ligand engagement, CD64 participates in signaling pathways regulating phagocytosis, antigen presentation, cytokine release, respiratory burst activation, and antibody-dependent cellular cytotoxicity. The receptor plays an important role in host defense against bacterial and viral pathogens and contributes to inflammatory responses within both innate and adaptive immune systems.
CD64 expression is particularly enriched in monocyte and macrophage populations and may increase substantially during inflammatory activation, infection, or interferon gamma stimulation. Because of its strong expression on activated myeloid cells, CD64 is widely used as a marker in flow cytometry, immunophenotyping, sepsis research, leukemia characterization, and inflammatory disease studies. Elevated CD64 expression has additionally been associated with autoimmune disease, chronic inflammation, and tumor-associated immune microenvironment regulation.
FCGR1A functions together with Fc receptor signaling adaptors including FcR gamma chain-containing complexes that activate downstream tyrosine kinase signaling pathways involved in immune cell activation and cytoskeletal remodeling. The receptor contributes to immune complex clearance, antibody-mediated pathogen recognition, and inflammatory signaling responses in activated leukocytes. Due to its broad immunologic importance, CD64 remains a highly utilized target in immunology and translational immune monitoring research.
CD64 is encoded on human chromosome 1q21 and produces a type I transmembrane glycoprotein containing extracellular immunoglobulin-like domains involved in IgG binding. The receptor localizes primarily to the plasma membrane of myeloid lineage cells and participates in Fc-mediated immune activation pathways. Immunophenotyping studies commonly demonstrate strong surface expression in monocyte and macrophage populations within peripheral blood mononuclear cells.
This mouse monoclonal CD64 antibody clone 10.1 has been widely utilized in published immunology research and is supported by more than 700 scientific publications. Flow cytometry analysis of peripheral blood mononuclear cells further supports selective surface detection of endogenous CD64-positive immune cell populations consistent with known FCGR1A expression patterns in activated myeloid cells.
Explore the broader CD Antibodies page for additional antibodies targeting leukocyte differentiation markers, immune receptors, and cell surface proteins involved in innate and adaptive immune signaling pathways.
Optimal dilution of the CD64 Antibody / High-Affinity Fc Gamma Receptor should be determined by the researcher.
Rheumatoid synovial fluid cells and human monocytes were used as the immunogen for the CD64 antibody.
Store the CD64 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
FCGR1A antibody, Fc gamma receptor 1A antibody, Fc gamma RI antibody, CD64 monocyte marker antibody, High-affinity IgG receptor antibody
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