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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CD5 Rabbit Polyclonal Antibody / Lymphocyte Surface Glycoprotein Antibody (F43040)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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F43040-0.4ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.4 ml | 439 | |
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F43040-0.08ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.08 ml | 205 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Purity | Antigen affinity |
| UniProt | P06127 |
| Applications | Western blot: 1:1000 IHC (Paraffin): 1:10-1:50 |
| Limitations | This CD5 Rabbit Polyclonal Antibody / Lymphocyte Surface Glycoprotein Antibody is available for research use only. |
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CD5 Rabbit Polyclonal Antibody / Lymphocyte Surface Glycoprotein Antibody targets CD5, a type I transmembrane glycoprotein belonging to the scavenger receptor cysteine-rich (SRCR) superfamily. CD5 is expressed predominantly on T lymphocytes and selected B-cell populations, where it functions as a cell surface marker and regulator of antigen receptor signaling. The protein contains three extracellular SRCR domains, a transmembrane region, and a cytoplasmic tail involved in intracellular signaling. CD5 contributes to immune homeostasis by influencing lymphocyte activation thresholds and regulating cellular responses to antigen recognition.
During T-cell development, CD5 expression is closely associated with the strength of signaling through the T-cell receptor (TCR). Developing thymocytes adjust CD5 expression in response to interactions between their TCRs and self-peptide-MHC complexes. Higher CD5 expression generally correlates with stronger self-reactivity, reflecting its role in modulating TCR signaling and maintaining appropriate activation thresholds. In mature T cells, CD5 participates in signaling networks that influence proliferation, survival, and immune responsiveness. These regulatory functions help balance effective antigen recognition with mechanisms that limit excessive immune activation.
CD5 is also expressed by certain B-cell subsets, including populations associated with natural antibody production and immune regulation. Its expression has particular significance in hematologic malignancies, where CD5 serves as an important immunophenotypic marker. Chronic lymphocytic leukemia and mantle cell lymphoma frequently exhibit CD5 expression, although the protein can also be detected in other lymphoid neoplasms. Because CD5 is not exclusive to a single lymphocyte lineage or malignancy, its expression is generally interpreted alongside additional markers when characterizing immune cell populations and lymphoproliferative disorders.
As a membrane glycoprotein, CD5 undergoes post-translational glycosylation that influences its apparent molecular weight. Although its predicted molecular mass is approximately 55 kDa, mature CD5 commonly migrates at a higher molecular weight because of carbohydrate modifications. Differences in glycosylation and cellular processing can contribute to variation in electrophoretic migration. Understanding these properties is important when evaluating CD5 protein expression and distinguishing its mature glycosylated form from the predicted polypeptide mass.
CD5 Rabbit Polyclonal Antibody supports research into lymphocyte differentiation, antigen receptor signaling, immune tolerance, and lymphoid malignancies. The relationship between CD5 expression and immune receptor responsiveness makes this protein particularly relevant to investigations of T-cell selection, B-cell biology, and the regulatory mechanisms governing adaptive immunity.
A full range of CD5 antibody reagents for immunohistochemistry, western blot, and flow cytometry is available on our CD5 Antibody collection page.
Titration of the CD5 Rabbit Polyclonal Antibody / Lymphocyte Surface Glycoprotein Antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 203-232 from the human protein was used as the immunogen for this CD5 antibody.
Aliquot the CD5 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
CD5 antibody, CD5 polyclonal antibody, T cell surface glycoprotein CD5 antibody, T-cell differentiation antigen CD5 antibody, LEU1 antibody, Leu-1 antibody, Lymphocyte antigen CD5 antibody, CD5 cell surface antigen antibody, CD5 glycoprotein antibody, CD5 T lymphocyte marker antibody
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