- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CD5 Antibody Clone CRIS-1 / Immune Checkpoint-Associated Marker Antibody [clone CRIS-1] (V2038)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V2038-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
|
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V2038-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
|
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V2038SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2a, kappa |
| Clone Name | CRIS-1 |
| Purity | Protein G affinity chromatography |
| Buffer | 1X PBS, pH 7.4 |
| Gene ID | 921 |
| Localization | Cell surface |
| Applications | Flow Cytometry : 0.5-1ug/10^6 cells Immunofluorescence : 0.5-1ug/ml Functional Studies (order BSA/sodium Azide-free Format) : Immunoprecipitation (0.5-1ug/500ug Protein Lysate) : |
| Limitations | This CD5 Antibody Clone CRIS-1 / Immune Checkpoint-Associated Marker Antibody is available for research use only. |
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CD5 (CD5) is a transmembrane glycoprotein expressed on T lymphocytes and a subset of B cells, where it functions as a regulator of immune signaling. CD5 Antibody / Immune Checkpoint-Associated Marker Antibody is used to detect CD5 in the context of immune regulation, where it exhibits checkpoint-like properties by modulating activation thresholds and maintaining signaling balance. CD5 antibody, also known as T cell surface glycoprotein CD5 antibody or LEU1 antibody, is widely used in studies of immune control mechanisms and regulatory signaling pathways.
CD5 acts as a negative regulator of antigen receptor signaling, attenuating T cell receptor activation and preventing excessive immune responses. This function aligns with broader immune checkpoint mechanisms that maintain immune homeostasis and prevent overactivation. By limiting signaling intensity, CD5 contributes to controlled immune responses and helps prevent tissue damage associated with uncontrolled inflammation. CD5 antibody is therefore useful for investigating signaling pathways that regulate immune activation and suppression.
Expression of CD5 on T cells allows it to influence signaling thresholds in response to antigenic stimulation, shaping the magnitude and duration of immune responses. This regulatory role is particularly important in maintaining balance between effective immunity and immune tolerance. CD5 antibody enables detection of this regulatory molecule in systems examining immune checkpoint-like signaling and control mechanisms.
In disease contexts, dysregulation of checkpoint-associated pathways can contribute to cancer progression, immune evasion, and chronic inflammatory conditions. CD5 is increasingly recognized as part of these regulatory networks, where its signaling function influences immune cell behavior. CD5 antibody supports studies exploring these processes by enabling detection of CD5 in models of immune dysfunction and therapeutic response.
CD5 is also relevant in studies of chronic immune activation and T cell exhaustion, where regulatory signaling pathways shape long-term immune function. Detection of CD5 provides insight into how immune cells maintain balance under sustained stimulation conditions and how regulatory mechanisms adapt over time.
This antibody is suitable for detecting CD5 in research applications focused on immune regulation and checkpoint-associated signaling. Its ability to identify CD5 supports studies of immune control mechanisms, signaling inhibition, and disease-associated immune dysfunction.
Because CD5 functions as a regulator of immune signaling, CD5 antibody is widely used in studies of immune checkpoint biology, signaling control, and immune system regulation.
A full range of CD5 antibody reagents for immunohistochemistry, western blot, and flow cytometry is available on our CD5 Antibody collection page.
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the CD5 Antibody Clone CRIS-1 / Immune Checkpoint-Associated Marker Antibody to be titered up or down for optimal performance.
Stimulated human leukocytes were used as the immunogen for this CD5 antibody.
Store the CD5 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
CD5 clone CRIS-1 antibody, CD5 CRIS-1 antibody, CD5 monoclonal antibody CRIS-1, CD5 immune marker antibody, CD5 lymphocyte surface antibody
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