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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CD5 Antibody / Rat Reactive Immune Marker Antibody [clone 11B4] (RQ6376)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ6376 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
| Availability | 1-3 business days |
| Species Reactivity | Rat |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1 |
| Clone Name | 11B4 |
| Purity | Antigen affinity purified |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | Q4KLZ9 |
| Localization | Cell surface |
| Applications | Western Blot : 0.5-1ug/ml Immunohistochemistry (FFPE) : 2-5ug/ml |
| Limitations | This CD5 Antibody / Rat Reactive Immune Marker Antibody is available for research use only. |
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CD5 (CD5) is a type I transmembrane glycoprotein belonging to the scavenger receptor cysteine-rich (SRCR) superfamily, localized to the plasma membrane of T lymphocytes and a subset of B cells. CD5 Antibody - Rat Reactive Immune Marker Antibody is raised against a rat amino acid sequence, enabling targeted recognition of CD5 in rat-derived samples for both tissue-based and protein-based analysis. CD5 antibody, also known as T cell surface glycoprotein CD5 antibody or LEU1 antibody, is widely used as a defining marker of lymphocyte populations and plays a central role in studies of immune system organization in preclinical rat models.
CD5 is highly expressed during thymocyte development and remains consistently present on mature peripheral T cells, where it functions as a key regulator of antigen receptor signaling. By modulating T cell receptor (TCR) activation thresholds, CD5 contributes to immune tolerance and helps prevent excessive immune responses. Its expression also extends to a subset of B cells, particularly those associated with innate-like immune functions. Because of this tightly regulated and lineage-associated expression pattern, CD5 antibody is commonly used to study lymphocyte identity, immune cell distribution, and activation states. In rat systems, these properties are especially important for investigating immune development, inflammation, and disease progression in controlled experimental settings.
CD5 Antibody raised against a rat sequence provides strong and biologically relevant detection of CD5 in rat tissues, supporting immunohistochemistry analysis of formalin-fixed, paraffin-embedded samples. In IHC applications, CD5 staining produces a distinct membranous pattern in T cell-rich regions such as thymus, lymph node, and spleen, clearly outlining lymphoid architecture and enabling visualization of immune cell localization within tissue compartments. This is particularly valuable in rat models of cancer, autoimmune disease, and inflammatory conditions, where spatial assessment of immune infiltration and lymphocyte distribution is essential for interpreting disease mechanisms.
In western blot applications, CD5 is detected as a glycosylated membrane protein that often migrates at an apparent molecular weight higher than its predicted size due to post-translational modification. CD5 antibody for WB enables detection of this characteristic band in rat tissue lysates, supporting confirmation of protein expression and analysis of immune-related signaling pathways. The ability to assess CD5 at the protein level complements histological findings and allows researchers to evaluate changes in expression under different experimental conditions, including stimulation, disease progression, or therapeutic intervention.
This mouse monoclonal CD5 antibody (clone 11B4) is well suited for research applications involving rat samples, providing consistent detection of CD5 across immunohistochemistry and western blot assays. Its sequence-directed design enhances recognition of rat CD5 and supports reproducible performance in studies requiring reliable identification of lymphocyte-associated proteins.
Given the widespread use of rat models in immunology, oncology, and translational research, CD5 antibody targeting rat CD5 is a valuable tool for studying immune cell composition, lymphoid tissue organization, and disease-associated changes in lymphocyte populations. Its ability to support both tissue-level visualization and protein-level detection makes it particularly useful for integrated experimental approaches aimed at understanding immune system function in vivo.
A full range of CD5 antibody reagents for immunohistochemistry, western blot, and flow cytometry is available on our CD5 Antibody collection page.
Optimal dilution of the CD5 Antibody / Rat Reactive Immune Marker Antibody should be determined by the researcher.
Recombinant rat protein (amino acids Q24-L494) was used as the immunogen for the CD5 antibody.
After reconstitution, the CD5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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