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Home >> Antibodies >> CD46 Antibody

CD46 Antibody [clone MCP/931] (V8798)

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  Catalog No Formulation Size Price (USD)  
Image V8798-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V8798-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V8798SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2a, kappa
Clone Name MCP/931
Purity Protein affinity
UniProt P15529
Localization Cell Surface
Applications Flow cytometry : 1-2ug/million cells
Immunofluorescence : 1-2ug/ml
Limitations This CD46 antibody is available for research use only.
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Description

CD46 exists as many isoforms in a variety of tissues. It is strongly expressed on salivary gland ducts and kidney ducts, moderately on lymphocytes and endothelium, and weakly on interstitial tissues and muscle cells, but not on erythrocytes. CD46 functions as a C3b/C4b-binding glycoprotein that inhibits complement activation on host cells. It also serves as a measles virus receptor, an adherence factor for group A Streptococcus pyogenes, and a cellular pilus receptor for pathogenic Neisseria.

Application Notes

Optimal dilution of the CD46 antibody should be determined by the researcher.

Immunogen

Recombinant human CD46 protein was used as the immunogen for the CD46 antibody.

Storage

Aliquot the CD46 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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