- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CD45RA Antibody [clone T200/8144R] (V4765)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4765-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
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V4765-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
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V4765SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | T200/8144R |
| Purity | Protein A/G affinity |
| UniProt | P08575 |
| Localization | Cell surface, Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This CD45RA antibody is available for research use only. |
|
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CD45RA antibody targets CD45RA, an alternatively spliced isoform of Protein tyrosine phosphatase receptor type C encoded by the PTPRC gene. CD45 is expressed on nearly all nucleated hematopoietic cells and functions as a key regulator of antigen receptor signaling. The CD45RA isoform is primarily associated with naive CD4+ and CD8+ T cells, where it contributes to the regulation of T cell receptor signaling intensity and activation thresholds. CD45RA antibody enables differentiation between naive and memory T cell subsets in lymphoid tissues and peripheral blood.
The CD45 molecule consists of a heavily glycosylated extracellular domain, a transmembrane region, and tandem intracellular phosphatase domains. Alternative splicing of exons 4, 5, and 6 produces distinct isoforms including CD45RA, CD45RB, and CD45RO. CD45RA antibody detects the exon A-containing isoform, which is characteristically expressed on resting naive T lymphocytes. Upon antigen exposure and differentiation into memory cells, expression shifts toward CD45RO.
Abnormal expression patterns of CD45 isoforms have been observed in leukemias, lymphomas, and immune dysregulation syndromes. CD45RA antibody is a valuable tool for characterizing immune cell subsets in research studies involving adaptive immunity, transplantation biology, and tumor immunology.
Optimal dilution of the CD45RA antibody should be determined by the researcher.
Recombinant full-length human PTPRC protein was used as the immunogen for the CD45RA antibody.
Aliquot the CD45RA antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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