- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CD45RA Antibody [clone PTPRC/8341R] (V4775)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4775-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V4775-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
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V4775SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | PTPRC/8341R |
| Purity | Protein A/G affinity |
| UniProt | P08575 |
| Localization | Cell surface, Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This CD45RA antibody is available for research use only. |
|
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CD45RA antibody recognizes CD45RA, a high molecular weight isoform of the Leukocyte common antigen encoded by the PTPRC gene. CD45RA is generated through alternative splicing of exons within the PTPRC transcript and is predominantly expressed on naive T lymphocytes and a subset of B cells. As a transmembrane protein tyrosine phosphatase, CD45 plays a central role in regulating antigen receptor signaling by modulating phosphorylation states of Src family kinases such as LCK and FYN. CD45RA antibody is widely used to distinguish naive T cells from memory T cell populations, as CD45RA expression is typically downregulated following antigen encounter and differentiation.
Structurally, CD45 contains an extracellular domain with multiple glycosylated regions, a single transmembrane segment, and two intracellular phosphatase domains. The extracellular region varies depending on splicing patterns, giving rise to CD45RA, CD45RB, and CD45RO isoforms. CD45RA antibody specifically detects the RA isoform, which includes exon A in the extracellular domain. CD45-mediated signaling is essential for proper T cell activation thresholds and immune homeostasis. Dysregulation of CD45 isoform expression has been implicated in autoimmune conditions and hematologic malignancies.
CD45RA antibody is suitable for detecting CD45RA expression in research applications investigating lymphocyte development, immune phenotyping, and tumor-infiltrating immune cells.
Optimal dilution of the CD45RA antibody should be determined by the researcher.
Recombinant full-length human PTPRC protein was used as the immunogen for the CD45RA antibody.
Aliquot the CD45RA antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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