- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CD45 Antibody SPM569 + SPM570 FITC Conjugate [clone SPM569 + SPM570] (V2402FITC)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V2402FITC-100T | 500 ul at 0.1 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 Tests | 559 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | FITC Conjugate |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa + Mouse IgG1, kappa |
| Clone Name | SPM569 + SPM570 |
| Purity | Protein G affinity chromatography |
| UniProt | P08575 |
| Localization | Cell surface, cytoplasmic |
| Applications | Flow Cytometry : 5ul/test/10^6 cells in 0.1ml |
| Limitations | This CD45 Antibody SPM569 + SPM570 FITC Conjugate is available for research use only. |
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CD45 Antibody SPM569 + SPM570 FITC Conjugate recognizes the CD45 leukocyte common antigen (LCA) family which is comprised of at least four isoforms of membrane glycoproteins (220, 205, 190, 180kDa) expressed on hematopoietic cell lines but absent on non-hematopoietic cell lines, normal and malignant non-hematopoietic tissues. The intracellular portions of these molecules have protein phosphatase activity and are involved in regulation of transmembrane signals. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms. A positive result with this MAb is highly indicative of lymphoid or myeloid origin. Certain types of lymphoid neoplasms may lack CD45 (Hodgkin lymphoma, some T-cell lymphomas, and some leukemias) so its absence does not rule out a hematolymphoid tumor. This antibody is expressed almost exclusively by cells of hematopoietic lineage and is present in most benign and malignant lymphocytes as well as plasma cell precursors.
CD45 is encoded by PTPRC and functions as a key regulator of leukocyte signaling and hematopoietic cell biology; additional reagents targeting this protein are available on the CD45 Antibody page.
Optimal dilution of the CD45 Antibody SPM569 + SPM570 FITC Conjugate should be determined by the researcher.
Human B- and T-lymphoma cells were used as the immunogen for this antibody cocktail.
Store the CD45 antibody at 2-8oC, protected from light.
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