- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CD44v6 Antibody for IHC Esophageal Epithelium / Epithelial Differentiation Marker Antibody [clone CD44V6/2496] (V3775)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V3775-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V3775-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V3775SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | CD44V6/2496 |
| Purity | Protein G affinity chromatography |
| UniProt | P16070 |
| Localization | Cell surface, cytoplasmic |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This CD44v6 Antibody for IHC Esophageal Epithelium / Epithelial Differentiation Marker Antibody is available for research use only. |
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CD44 antigen (CD44) is a transmembrane glycoprotein of the CD44 family that functions as a receptor for hyaluronic acid and mediates cell adhesion, migration, and extracellular matrix interactions. It is localized primarily to the cell membrane of epithelial and hematopoietic cells, where it plays a central role in maintaining tissue architecture and regulating cell-cell communication. CD44v6 Antibody for IHC Esophageal Epithelium is designed to detect the variant 6-containing isoform of CD44 in formalin-fixed, paraffin-embedded tissues, enabling immunohistochemistry-based evaluation of epithelial differentiation and structural organization in stratified squamous tissues. CD44v6 is prominently expressed across epithelial cell layers where coordinated differentiation and maturation define tissue architecture.
CD44 antibody, also referred to as CD44 antigen antibody, CD44 variant 6 antibody, CD44v6 IHC antibody, or Hermes antigen antibody, recognizes alternatively spliced isoforms that confer distinct biological functions. CD44v6 expression is closely associated with epithelial differentiation states, with strong membranous localization observed across basal, suprabasal, and intermediate layers of stratified squamous epithelium. Mouse monoclonal antibody clone CD44V6/2496 is designed to detect CD44v6 in tissue sections, enabling high-resolution visualization of epithelial morphology and differentiation patterns within esophageal mucosa.
Functionally, CD44v6 contributes to the regulation of epithelial cell maturation by supporting adhesion and maintaining spatial organization across differentiating cell layers. In stratified squamous epithelium, its expression reflects a coordinated differentiation gradient extending from proliferative basal cells to more differentiated superficial layers. In immunohistochemistry applications, CD44v6 staining presents as strong, crisp membranous HRP-DAB signal outlining individual cell borders, allowing precise visualization of epithelial stratification, cellular morphology, and differentiation states. This CD44v6 Antibody for IHC Esophageal Epithelium is particularly suited for examining epithelial maturation, layer organization, and structural clarity in normal tissues.
In addition to its role in normal epithelial biology, CD44v6 expression provides a sensitive readout of changes in epithelial differentiation that may occur in pathological conditions. Alterations in staining intensity, continuity, or distribution can reflect disruptions in epithelial maturation and tissue organization, supporting comparative analysis between normal and diseased states. The clear delineation of epithelial layers provided by CD44v6 staining makes it especially useful for evaluating subtle changes in tissue structure and differentiation patterns.
Structurally, CD44 is encoded on chromosome 11p13 and consists of an extracellular ligand-binding domain, a transmembrane segment, and a cytoplasmic tail involved in intracellular signaling and cytoskeletal interactions. The variant 6 region is generated through alternative splicing within the extracellular domain, producing isoforms with specialized roles in adhesion and epithelial organization. CD44 isoforms are differentially expressed depending on tissue type and biological context, with CD44v6 commonly enriched in stratified epithelial tissues. An antibody targeting CD44v6 is suitable for detecting variant-specific expression in esophageal epithelium and related research applications involving epithelial differentiation and tissue organization.
This CD44v6 antibody is part of a broader CD44 antibody panel offered by NSJ Bioreagents.
Titering of the CD44v6 Antibody for IHC Esophageal Epithelium / Epithelial Differentiation Marker Antibody may be required for optimal performance.
An amino acid sequence from the variant 6 domain of CD44 was used as the immunogen for the CD44v6 antibody.
Store the CD44v6 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
CD44v6 antibody, CD44 variant 6 antibody, CD44 splice variant antibody, CD44 epithelial differentiation marker antibody, Hermes antigen variant antibody
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