- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CD44v4 Antibody for IHC Squamous Cell Carcinoma / SCC Marker Antibody [clone CD44v4/1219] (V3282)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V3282-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V3282-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V3282SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2a, kappa |
| Clone Name | CD44v4/1219 |
| Purity | Protein G affinity chromatography |
| UniProt | P16070 |
| Localization | Cell surface, cytoplasmic |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This CD44v4 Antibody for IHC Squamous Cell Carcinoma / SCC Marker Antibody is available for research use only. |
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CD44 antigen (CD44) is a transmembrane glycoprotein of the CD44 family that functions as a receptor for hyaluronic acid and mediates cell adhesion, migration, and extracellular matrix interactions. It is localized primarily to the cell membrane of epithelial and hematopoietic cells, where it contributes to maintenance of tissue architecture and intercellular communication. CD44v4 Antibody for IHC Squamous Cell Carcinoma is designed to detect the variant 4-containing isoform of CD44 in formalin-fixed, paraffin-embedded tissues, enabling immunohistochemistry-based evaluation of squamous epithelial tumors and their structural differentiation. CD44v4 expression is associated with epithelial cohesion and is commonly retained in squamous-derived malignancies where tumor cells preserve characteristic stratified organization.
CD44 antibody, also referred to as CD44 antigen antibody, CD44 variant 4 antibody, CD44v4 IHC antibody, or Hermes antigen antibody, recognizes alternatively spliced isoforms that confer distinct biological functions. CD44v4 is linked to maintenance of squamous epithelial identity through membrane-associated adhesion and preservation of organized cell-cell contacts. In stratified squamous epithelium, expression is typically observed in basal and suprabasal layers, reflecting regions of active proliferation and differentiation. Mouse monoclonal antibody clone CD44v4/1219 is designed to detect CD44v4 in tissue sections, supporting identification of squamous tumor cell populations and evaluation of epithelial lineage characteristics in carcinoma samples. A recombinant form of this clone is also available, enabling complementary approaches to CD44v4 detection across related antibody formats.
Functionally, CD44v4 contributes to structural cohesion within stratified squamous epithelium by supporting adhesion between neighboring cells and maintaining organized epithelial layering. In squamous cell carcinoma, this pattern of membranous expression is frequently preserved within malignant epithelial nests and sheets, allowing clear visualization of tumor architecture and differentiation state. In immunohistochemistry applications, CD44v4 staining presents as strong membranous HRP-DAB signal outlining tumor cell borders and maintaining recognizable squamous organization. This CD44v4 Antibody for IHC Squamous Cell Carcinoma is particularly suited for identifying squamous epithelial character and supporting classification of SCC in tissue sections.
CD44v4 expression is observed in squamous malignancies including cervical squamous cell carcinoma and tongue squamous cell carcinoma, where it highlights malignant epithelial cells and supports assessment of tumor morphology. Its distribution in these tissues provides a useful marker for evaluating epithelial lineage and distinguishing tumors with preserved squamous differentiation from less organized malignancies. Detection of CD44v4 in SCC therefore supports studies of tumor architecture, epithelial identity, and tissue-based classification in squamous neoplasia.
Structurally, CD44 is encoded on chromosome 11p13 and consists of an extracellular ligand-binding domain, a transmembrane segment, and a cytoplasmic tail involved in intracellular signaling and cytoskeletal interactions. The variant 4 region is generated through alternative splicing within the extracellular domain, producing isoforms with specialized roles in adhesion and epithelial organization. CD44 isoforms are differentially expressed depending on tissue type and biological context, with CD44v4 commonly associated with epithelial cohesion and structural maintenance. An antibody targeting CD44v4 is suitable for detecting variant-specific expression in squamous epithelial tumors and related research applications involving epithelial differentiation and tumor classification.
This CD44v4 antibody is part of a broader CD44 antibody panel offered by NSJ Bioreagents.
Titering of the CD44v4 Antibody for IHC Squamous Cell Carcinoma / SCC Marker Antibody may be required for optimal performance.
An amino acid sequence from the variant 4 domain of CD44 was used as the immunogen for the CD44v4 antibody.
Store the CD44v4 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
CD44v4 antibody, CD44 variant 4 antibody, CD44 splice variant antibody, CD44 squamous marker antibody, Hermes antigen variant antibody
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