- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CD40L Antibody / TNFSF5 Antibody [clone CD40LG/2763] (V8248)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V8248-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V8248-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V8248SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | CD40LG/2763 |
| Purity | Protein G affinity chromatography |
| UniProt | P29965 |
| Localization | Cell surface, secreted |
| Applications | ELISA (order BSA-free Format For Coating) : Flow Cytometry : 1-2ug/10^6 cells in 0.1ml Immunofluorescence : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This CD40L Antibody / TNFSF5 Antibody is available for research use only. |
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CD40L Antibody / TNFSF5 Antibody recognizes CD40 ligand, a member of the tumor necrosis factor ligand superfamily encoded by the CD40LG gene. Also known as CD154, TNFSF5 and TRAP, CD40L is a cell-surface and soluble immune signaling protein with an important role in communication between activated T cells and CD40-expressing cells. CD40L expression is particularly associated with activated CD4-positive T cells and is induced rapidly following T-cell activation, making the protein an important marker and mediator of adaptive immune responses.
CD40L binds CD40, a receptor expressed on several immune cell populations, including B cells, macrophages and dendritic cells. CD40-CD40L interactions provide costimulatory signals that help coordinate cellular and humoral immunity. In B cells, engagement of CD40 by CD40L-expressing T cells contributes to proliferation, differentiation, immunoglobulin isotype switching and memory B-cell formation. CD40L can also promote activation of antigen-presenting cells and thereby influence antigen-specific T-cell responses.
CD40L signaling extends beyond direct T-cell and B-cell interactions. Activation of dendritic cells through CD40 can promote interleukin-12 production, while CD40-CD40L interactions involving other antigen-presenting cells can stimulate inflammatory mediators. The pathway therefore represents an important research target in T-cell activation, B-cell biology, immune costimulation, inflammation and mechanisms regulating adaptive immunity.
Clone CD40LG/2763 is a mouse monoclonal antibody generated using amino acids 108-261 of human CD40L as the immunogen. Its specificity has been evaluated on a HuProt protein microarray containing more than 19,000 full-length human proteins. In this assay, the Z-score represents antibody signal strength in standard deviations above the mean signal across the array, while the S-score measures separation between the intended target and the next highest-ranked protein and therefore indicates relative target specificity. Additional validation includes FFPE human spleen IHC and analysis of human Jurkat cells by immunofluorescence and flow cytometry.
A CD40L Antibody can be used to investigate TNFSF5 expression, CD40-CD40L interactions, T-cell activation and signaling mechanisms that regulate B-cell and antigen-presenting cell responses.
CD40L, also known as CD154 and TNFSF5, mediates immune costimulatory signaling through CD40; additional information on this pathway and target biology is available on the CD40 Ligand Antibody page.
Optimal dilution of the CD40L Antibody / TNFSF5 Antibody should be determined by the researcher.
A portion of amino acids 108-261 from the human protein was used as the immunogen for the CD40L antibody.
Store the CD40L antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
CD40L antibody, TNFSF5 antibody, CD40LG antibody, CD40 Ligand antibody, CD154 antibody, Tumor Necrosis Factor Ligand Superfamily Member 5 antibody
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