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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CD40 Antibody Mouse Monoclonal [clone CD40/4940] (V4832)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4832-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V4832-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V4832SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | CD40/4940 |
| Purity | Protein A/G affinity |
| UniProt | P25942 |
| Localization | Cell Surface, Secreted |
| Applications | ELISA (Order BSA-free Format For Coating) : Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This CD40 antibody is available for research use only. |
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CD40 antibody, also known as Tumor necrosis factor receptor superfamily member 5 antibody, recognizes a type I membrane receptor commonly referred to as Bp50 and CDw40. In B cells and professional antigen-presenting cells, CD40 is localized to the plasma membrane where it functions as a key costimulatory receptor that integrates immune activation signals. For SEO consistency, the exact phrase CD40 Antibody Mouse Monoclonal is included here, while the biological context below describes the native CD40 molecule rather than assay-specific performance claims.
CD40 is encoded by the CD40 gene in humans on chromosome 20 and belongs to the tumor necrosis factor receptor superfamily. The extracellular region contains multiple cysteine-rich domains that support ligand binding, followed by a single-pass transmembrane helix and a cytoplasmic tail that recruits adaptor proteins. Engagement by its canonical ligand CD40L (CD154) promotes receptor clustering and triggers TRAF-dependent signaling, leading to activation of NF-kappaB, MAPK, and related transcriptional programs. These pathways drive antigen-presenting cell maturation, upregulation of costimulatory molecules, and cytokine production, while in B lymphocytes they support survival, germinal center responses, and immunoglobulin class switching. In addition to lymphoid tissues, CD40 expression is often detected on dendritic cells, macrophages, and subsets of epithelial or endothelial cells in inflammatory settings, reflecting its broader role in immune-stromal communication.
CD40 biology is tightly linked to disease mechanisms. Disruption of the CD40-CD40L axis is associated with immunodeficiency phenotypes involving impaired T cell help and defective antibody class switching, and dysregulated signaling can contribute to chronic inflammation and autoimmunity. In oncology, CD40 is frequently discussed in the context of B-cell malignancies and the tumor microenvironment, where CD40 pathway activity can influence antigen presentation, immune infiltration, and sensitivity to immunomodulatory therapies. Alternative splicing and receptor processing have been reported for several TNF receptor family members, and CD40 signaling output can vary by cell type depending on adaptor availability and activation state. Clone CD40/4940 is designed to target CD40 for research applications where detection of CD40 expression and localization is needed in relevant experimental models.
Optimal dilution of the CD40 antibody should be determined by the researcher.
A recombinant fragment of human CD40 protein (around aa 1-200) was used as the immunogen for the CD40 antibody.
Aliquot the CD40 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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