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Home >> Antibodies >> CD4 Antibody

CD4 Antibody [clone CD4/1604] (V9139)

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  Catalog No Formulation Size Price (USD)  
Image V9139-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V9139-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V9139SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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FACS staining of lymphocyte-gated human PBM cells with CD4 antibody (red, clone CD4/1604) and isotype control (gray).
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FACS staining of lymphocyte-gated human PBM cells with CD4 antibody (red, clone CD4/1604) and isotype control (gray).
SDS-PAGE analysis of purified, BSA-free CD4 antibody (clone CD4/1604) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2b, kappa
Clone Name CD4/1604
Purity Protein A/G affinity
UniProt P01730
Localization Cell Surface
Applications ELISA (order BSA-free format for coating) :
Flow cytometry : 1-2ug/million cells
Limitations This CD4 antibody is available for research use only.
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Description

Recognizes a protein of 55kDa, identified as CD4. It is a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigens and is also a receptor for the human immunodeficiency virus. This protein is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. The majority of peripheral T-cell lymphomas are derived from the T-helper/regulatory cell subset so that most mature T-cell neoplasms are CD4+/CD8-. Anti-CD4 is used in the immunohistochemical staining of lymphoproliferative disorders to evaluate tumors with CD4 aberrant expression.

Application Notes

Optimal dilution of the CD4 antibody should be determined by the researcher.

Immunogen

A portion of amino acids 245-392 was used as the immunogen for the CD4 antibody.

Storage

Aliquot the CD4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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