- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CD3e Antibody Clone UCHT1 / CD3 Epsilon Monoclonal Antibody [clone UCHT1] (V3760)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V3760-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
|
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V3760-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V3760SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | UCHT1 |
| Purity | Protein G affinity chromatography |
| UniProt | P07766 |
| Localization | Cell surface and cytoplasmic |
| Applications | ELISA : 2-4ug/ml (order BSA/azide-free format) Flow Cytometry : 1-2ug/million cells Immunofluorescence : 1-2ug/ml Immunohistochemistry (Acetone-fixed Frozen Tissues) : 1-2ug/ml for 30 min at RT Western Blot : 2-4ug/ml |
| Limitations | This CD3e antibody is available for research use only. |
|
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CD3 epsilon (CD3E) is a membrane-associated signaling component of the T-cell receptor (TCR) complex that is uniformly expressed on T lymphocytes and is essential for antigen recognition and downstream signaling. CD3e Antibody Clone UCHT1 / CD3 Epsilon Monoclonal Antibody enables detection of CD3 Epsilon / CD3E and serves as a foundational reagent for identifying T-cell populations. CD3e antibody, also known as CD3 epsilon antibody or CD3E antibody, is widely recognized as a pan-T cell marker antibody and is central to studies of adaptive immunity.
Within the TCR complex, CD3 epsilon associates with CD3 gamma, CD3 delta, and CD3 zeta chains to form a signaling unit that couples with the TCR alpha-beta or gamma-delta heterodimer. This complex is localized at the cell surface and is responsible for initiating intracellular signaling cascades following antigen engagement. These pathways regulate T-cell activation, proliferation, differentiation, and effector function, making CD3 epsilon a critical molecule for studying immune responses. Because of its stable and consistent expression, CD3e antibody reagents are widely used to define T-cell populations across a variety of experimental systems.
CD3e Antibody Clone UCHT1 is uniquely positioned as a high-confidence, widely adopted reagent due to its extensive presence in peer-reviewed literature, with over one thousand publications referencing its use. This broad literature representation reflects long-standing use across diverse immunological applications and provides strong support for its reliability as a CD3 detection tool. The widespread adoption of clone UCHT1 makes it a reference-standard reagent for many researchers, particularly in studies where consistency with established methods is important.
In experimental workflows, CD3e antibody reagents are used to identify T cells within complex biological samples, including peripheral blood, lymphoid tissues, and cultured cell populations. The ability to accurately detect CD3-positive cells is fundamental for downstream analyses such as T-cell subset characterization, immune profiling, and signaling studies. Clone UCHT1 supports these applications by providing consistent and reproducible detection of CD3 epsilon across sample types.
The extensive literature footprint of clone UCHT1 also enhances its value in comparative and translational studies. Researchers frequently select highly cited clones to align their experimental design with previously published data, improving comparability and interpretability of results. This is particularly relevant in large-scale studies or collaborative projects where standardization of reagents contributes to reproducibility.
As a monoclonal antibody, clone UCHT1 provides consistent epitope recognition and stable performance across experiments. Its long-standing use in the field, combined with strong literature support, positions CD3e Antibody Clone UCHT1 as a reliable and well-established tool for detecting CD3 epsilon. This clone remains a cornerstone reagent for T-cell identification and analysis in immunology research.
A full range of CD3e antibody reagents for immunohistochemistry, western blot, and flow cytometry is available on our CD3e Antibody collection page.
Optimal dilution of the CD3e Antibody Clone UCHT1 / CD3 Epsilon Monoclonal Antibody should be determined by the researcher.
Human infant thymocytes and peripheral blood lymphocytes from a Sezary Syndrome donor were used as the immunogen for the CD3e Antibody Clone UCHT1 / CD3 Epsilon Monoclonal Antibody.
Store the CD3e antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
CD3E antibody, CD3 epsilon UCHT1 antibody, CD3 UCHT1 monoclonal antibody, CD3 T cell marker antibody, CD3 antigen epsilon chain antibody
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