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- Tel: 858.663.9055
- Email: info@nsjbio.com
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The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [RefSeq]
Optimal dilution of the CD3e antibody should be determined by the researcher.
A synthetic peptide specific to mouse CD3 epsilon / CD3E was used as the immunogen for the CD3e antibody.
Store the CD3e antibody at -20oC.
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