- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CD39 Antibody Recombinant Mouse MAb [clone rCD39/8682] (V4117)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V4117-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V4117-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V4117SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG1, kappa |
| Clone Name | rCD39/8682 |
| Purity | Protein A/G affinity |
| UniProt | P49961 |
| Localization | Cell surface |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT |
| Limitations | This CD39 antibody is available for research use only. |
|
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CD39 Antibody recognizes CD39, also known as Ectonucleoside triphosphate diphosphohydrolase 1, a membrane-bound ectoenzyme encoded by the ENTPD1 gene that regulates extracellular nucleotide metabolism and purinergic signaling. CD39 is expressed on endothelial cells, regulatory T cells, B cells, monocytes, macrophages, and certain epithelial populations, where it modulates inflammatory and immune responses. CD39 Antibody is suitable for detecting CD39 expression in research applications involving immune regulation, vascular biology, and tumor microenvironment studies.
CD39 antibody, also referred to as ENTPD1 antibody and NTPDase1 antibody in the literature, targets an ectoenzyme that hydrolyzes extracellular ATP and ADP into AMP. By limiting pro-inflammatory ATP levels and contributing to adenosine generation in cooperation with CD73, CD39 plays a central role in immune suppression, thromboregulation, and maintenance of tissue homeostasis. CD39 expression is particularly relevant in regulatory T cells and in the tumor microenvironment, where it supports immunomodulatory pathways.
The ENTPD1 gene is located on chromosome 10q24.1 and encodes a glycosylated transmembrane protein containing two membrane-spanning domains and a large extracellular catalytic region with conserved apyrase motifs required for nucleotide hydrolysis. CD39 localizes predominantly to the plasma membrane and is highly expressed in vascular endothelium, lymphoid tissues, and placenta. Its tissue distribution reflects its physiologic role in regulating extracellular nucleotide concentrations and vascular function.
Altered CD39 expression has been implicated in cancer immune evasion, chronic inflammatory disorders, thrombosis, and cardiovascular disease. In histologic sections, CD39 typically demonstrates membranous staining in endothelial and immune cell populations. Clone rCD39/8682 is a recombinant mouse monoclonal antibody developed to recognize CD39 in experimental systems.
Optimal dilution of the CD39 antibody should be determined by the researcher.
Recombinant full-length human CD39 protein was used as the immunogen for the CD39 antibody.
Aliquot the CD39 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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