- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CD39 Antibody Rabbit Polyclonal / ENTPD1 (RQ6480)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ6480 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Affinity purified |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | P49961 |
| Applications | Western Blot : 1-2ug/ml Immunohistochemistry (FFPE) : 2-5ug/ml Immunofluorescence : 5ug/ml Flow Cytometry : 1-3ug/million cells Direct ELISA : 0.1-0.5ug/ml |
| Limitations | This CD39 antibody is available for research use only. |
|
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CD39 Antibody recognizes CD39, also known as Ectonucleoside triphosphate diphosphohydrolase 1, a cell surface ectoenzyme encoded by the ENTPD1 gene that regulates extracellular nucleotide signaling. CD39 is a transmembrane glycoprotein expressed on endothelial cells, regulatory T cells, B cells, monocytes, macrophages, and certain epithelial populations. CD39 Antibody is suitable for detecting CD39 expression in research applications involving immune regulation, vascular biology, and tumor microenvironment studies.
CD39 antibody, also referred to as ENTPD1 antibody and Ectonucleoside triphosphate diphosphohydrolase 1 antibody in the literature, targets an ectoenzyme that hydrolyzes extracellular ATP and ADP into AMP. Through this enzymatic activity, CD39 modulates purinergic signaling pathways and plays a critical role in controlling inflammation, thrombosis, and immune tolerance. CD39 works functionally in concert with CD73 to generate adenosine, contributing to immunosuppressive signaling in regulatory T cells and within the tumor microenvironment.
The ENTPD1 gene is located on chromosome 10q24.1 and encodes a membrane-bound protein with two transmembrane domains and a large extracellular catalytic domain containing apyrase conserved regions essential for nucleotide hydrolysis. CD39 localizes predominantly to the plasma membrane and is highly expressed in vascular endothelium, lymphoid tissues, and placental trophoblasts. Expression patterns reflect its physiologic role in maintaining vascular homeostasis and regulating immune cell activation.
Altered CD39 expression has been implicated in cancer immune evasion, chronic inflammatory disorders, thrombosis, and cardiovascular disease. In histologic sections, CD39 typically demonstrates membranous staining in endothelial cells and immune cell subsets. A CD39 antibody is commonly applied in research settings to investigate purinergic signaling, immune suppression, and tumor-associated immune regulation. This rabbit polyclonal antibody targets CD39 for research applications.
Optimal dilution of the CD39 antibody should be determined by the researcher.
An E. coli-derived human protein (amino acids H79-E411) was used as the immunogen for the CD39 antibody.
After reconstitution, the CD39 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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