CD36 Antibody GPIIIb/1654 / Platelet glycoprotein 4 [clone GPIIIb/1654] (V3005)

Description

CD36 Antibody GPIIIb/1654 recognizes a protein of 80kDa-90kDa, identified as CD36. It is expressed on platelets, monocytes and macrophages, microvascular endothelial cells, erythrocyte precursors, mammary epithelial cells, and some macrophage derived dendritic cells. CD36 acts as a receptor for thrombospondin (TSP), collagen types I, IV and V, P. falciparum malaria-infected erythrocytes, and sickle erythrocytes. It also functions as a scavenger receptor, mediating macrophage uptake of oxidized low-density lipoprotein (LDL) and recognition of apoptotic polymorphonuclear leukocytes (PMN). CD36 plays a role in platelet aggregation, macrophage foam cell development, inflammation, and the tissue ischemia observed in sickle cell disease and cerebral malaria. Note that 1-4% of Japanese and East Asia population lack CD36.

Visit our CD36 Antibody page to discover additional antibodies against this Fatty Acid Translocase and multifunctional scavenger receptor involved in fatty acid uptake, cardiovascular biology, and cancer metabolism.

Application Notes

Optimal dilution of the CD36 antibody should be determined by the researcher.

1. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 min.

Immunogen

Recombinant human protein was used as the immunogen for the CD36 antibody.

Storage

Store the CD36 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).