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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Cluster of Differentiation 34 (CD34) is a transmembrane sialomucin glycoprotein encoded by the CD34 gene and is widely expressed on vascular endothelial cells as well as hematopoietic stem and progenitor cells. It plays a key role in cell adhesion, migration, and maintenance of vascular integrity and is considered a defining marker of endothelial cell identity. CD34 Antibody / Endothelial Cell Marker Antibody is widely used to identify endothelial cells within tissues, where it enables precise visualization of vascular structures and localization of endothelial-lined compartments.
CD34 antibody, also known as vascular endothelial marker antibody or angiogenesis marker antibody, produces a characteristic membranous staining pattern in endothelial cells that line blood vessels. This staining outlines capillaries, small vessels, and larger vascular channels with high clarity, allowing direct identification of endothelial cell boundaries and luminal surfaces. The continuous membranous signal enables clear discrimination of endothelial cells from surrounding stromal, epithelial, and immune cell populations within complex tissue environments.
This CD34 Antibody / Endothelial Cell Marker Antibody is uniquely positioned for defining endothelial cell populations, where the primary goal is accurate identification rather than quantification or functional analysis. CD34-positive endothelial cells can be readily distinguished based on both morphology and staining pattern, appearing as elongated, vessel-forming cells arranged in continuous tubular structures. This allows researchers to map vascular organization and identify endothelial compartments across a wide range of tissues.
In normal tissues, CD34 staining reveals well-organized vascular networks with uniform vessel architecture, including regularly spaced capillaries and clearly defined vascular channels. These patterns reflect stable endothelial organization and can serve as a reference for comparison with altered vascular states. The ability to consistently visualize these structures supports studies of tissue organization and vascular distribution.
In disease contexts, endothelial cell organization may become disrupted, and CD34 staining can reveal alterations in vessel morphology, distribution, and density. Although this page focuses on endothelial identification rather than specific biological processes, the clear visualization of endothelial cells allows indirect observation of structural changes associated with pathology.
While CD34 expression may also be detected in hematopoietic progenitor cells depending on tissue context, its most consistent and morphologically distinct localization remains within vascular endothelial cells. Interpretation of CD34 staining therefore relies on both signal localization and anatomical context to accurately identify endothelial populations.
Overall, CD34 Antibody / Endothelial Cell Marker Antibody HPCA1/8333R provides robust and consistent detection of endothelial cells, enabling clear identification of vascular structures and supporting detailed analysis of tissue architecture and cellular localization.
This antibody is part of our CD34 antibody collection, supporting research into stem cell biology, endothelial markers, and tumor angiogenesis.
Optimal dilution of the CD34 Antibody / Endothelial Cell Marker Antibody should be determined by the researcher.
Recombinant full-length human HPCA1 protein was used as the immunogen for the CD34 antibody.
Aliquot the CD34 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
CD34 endothelial cell marker antibody, vascular endothelial marker antibody, CD34 endothelial antibody, CD34 vessel lining marker antibody, CD34 endothelial identification antibody
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