- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CD27 Antibody Recombinant Rabbit MAb [clone LPFS2/8316R] (V4233)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4233-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V4233-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
|
V4233SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | LPFS2/8316R |
| Purity | Protein A/G affinity |
| UniProt | P26842 |
| Localization | Cell Surface |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT |
| Limitations | This CD27 antibody is available for research use only. |
|
Review this product on BioCompare and get a $20 Amazon gift card
|
Related Products
|
CD27 antibody recognizes CD27, a type I transmembrane glycoprotein and member of the tumor necrosis factor receptor superfamily encoded by the CD27 gene. CD27 is primarily localized to the plasma membrane of T lymphocytes, memory B cells, and subsets of natural killer cells, where it functions as a co-stimulatory receptor that promotes lymphocyte activation, survival, and differentiation. CD27 Antibody Recombinant Rabbit MAb supports research focused on adaptive immunity, lymphocyte maturation, and immune checkpoint signaling.
The CD27 gene is located on chromosome 12p13 and encodes a protein containing extracellular cysteine-rich domains characteristic of TNF receptor family members, a single transmembrane region, and a cytoplasmic tail that recruits TRAF adaptor proteins. Upon binding to its ligand CD70, CD27 triggers activation of NF-kappaB and related signaling pathways that enhance T-cell expansion, promote memory formation, and support B-cell differentiation. CD27 expression is tightly regulated during immune activation and is commonly used to distinguish naive, memory, and effector lymphocyte subsets.
In secondary lymphoid tissues such as tonsil and lymph node, CD27-positive cells are observed within T-cell zones and germinal center-associated compartments. CD27 is broadly expressed on naive and central memory T cells and on memory B cells, but expression may be reduced in terminally differentiated effector populations. Dysregulated CD27 signaling has been associated with chronic infection, autoimmunity, and certain lymphoid malignancies. CD27 Antibody Recombinant Rabbit MAb enables evaluation of CD27 distribution and expression dynamics in both normal immune responses and disease contexts.
The CD27-CD70 axis is actively investigated in immuno-oncology, as modulation of this pathway can enhance anti-tumor immune responses. Assessment of CD27 expression in tumor-infiltrating lymphocytes provides insight into activation status and immune microenvironment composition. Clone LPFS2/8316R is engineered as a recombinant rabbit monoclonal antibody to provide consistent specificity and reproducibility in CD27 detection.
By targeting a key co-stimulatory receptor of adaptive immunity, CD27 Antibody Recombinant Rabbit MAb provides a reliable reagent for studying lymphocyte biology, immune regulation, and translational immunotherapy research.
Optimal dilution of the CD27 antibody should be determined by the researcher.
Recombinant human full-length protein was used as the immunogen for the CD27 antibody.
Aliquot the CD27 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz
Citations(1)