Cd244 Antibody / Natural killer cell receptor 2B4 (RQ8880)

Description

CD244 (also known as 2B4 or SLAMF4) is an immunoreceptor expressed on NK cells, CD8+ T cells, gamma delta T cells, monocytes, and some dendritic cells. It binds CD48 to modulate cytotoxicity, cytokine secretion, and immune synapse formation. Signal polarity (activating vs. inhibitory) depends on adaptor usage, including SAP/SH2D1A and EAT-2, enabling context-specific tuning of effector function. The CD244 antibody helps delineate these pathways by resolving expression and activation states across cell subsets.

Dysregulated CD244 signaling is linked to impaired NK function in chronic viral infection, T cell exhaustion in tumors, and altered myeloid responses. Expression level, phosphorylation status, and adaptor association serve as readouts for immune competence in immuno-oncology, vaccine studies, and autoimmunity research, making precise detection with the CD244 antibody valuable for mechanistic and translational investigations.

The CD244 antibody supports applications such as flow cytometry, immunohistochemistry, and western blot to quantify receptor abundance, track subcellular localization, and assess pathway modulation under genetic or pharmacologic perturbation. With high specificity and reproducible performance across primary cells and model systems, the CD244 antibody enables rigorous analysis of NK and T cell biology.

Application Notes

Optimal dilution of the Cd244 antibody should be determined by the researcher.

Immunogen

Recombinant mouse protein (amino acids Q20-N374) was used as the immunogen for the Cd244 antibody.

Storage

After reconstitution, the Cd244 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.