- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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CD22 antibody is a useful reagent for detecting CD22, a B cell restricted glycoprotein encoded by the SIGLEC2 gene. CD22 functions as an inhibitory coreceptor, regulating B cell receptor signaling thresholds. It is expressed on the surface of mature B cells but absent from plasma cells, making it an important marker for B cell lineage studies. Because of its dual role as a signaling modulator and diagnostic marker, CD22 is studied in immunology, oncology, and therapeutic development.
CD22 belongs to the sialic acid binding immunoglobulin like lectin family. Its extracellular domain binds sialylated ligands, while its cytoplasmic tail contains immunoreceptor tyrosine based inhibitory motifs. These motifs recruit phosphatases that dampen B cell receptor signaling, preventing overactivation. This regulation ensures immune tolerance and reduces the risk of autoimmunity.
The CD22 antibody clone BLCAM/1795 provides consistent and specific recognition. Clone BLCAM/1795 has been used in research focused on B cell biology, autoimmune disease, and lymphoid malignancies. It is also valuable in translational contexts, where CD22 serves as a therapeutic target for monoclonal antibody based treatments of B cell leukemias and lymphomas. The antibodyâs specificity makes it a reliable choice for a wide range of applications.
Research using clone BLCAM/1795 has expanded knowledge of how CD22 maintains immune balance and influences B cell malignancies. Detection of CD22 contributes to the diagnosis and classification of leukemias and lymphomas, while therapeutic targeting of CD22 has produced effective treatments. This antibody continues to support both fundamental and clinical research.
NSJ Bioreagents provides this CD22 antibody to support immunology and oncology research. The protein is also known as SIGLEC2 antibody, B lymphocyte cell adhesion molecule antibody, BL CAM antibody, and sialic acid binding Ig like lectin 2 antibody.
Optimal dilution of the CD22 antibody should be determined by the researcher.
Amino acids 52-178 from the human protein were used as the immunogen for the CD22 antibody.
Store the CD22 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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