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- Tel: 858.663.9055
- Email: info@nsjbio.com
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Recognizes a protein of 130-140kDa, identified as CD22 (also known as BL-CAM). CD22 expression is restricted to normal and neoplastic B cells and is absent from other haemopoietic cell types. In B-cell ontogeny, CD22 is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. It is not expressed by plasma cells, CD22 is found highly expressed in follicular mantle and marginal zone B-cells, and while germinal center B-cells are relatively weak. CD22 is a member of the immunoglobulin superfamily and serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. It also associates with tyrosine kinases and play a role in signal transduction and B-cell activation.
Optimal dilution of the CD22 antibody should be determined by the researcher.
Amino acids 52-178 from the human protein were used as the immunogen for the CD22 antibody.
Store the CD22 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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