- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CD20 Antibody [clone L26] (V7645)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V7645-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 539 | |
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V7645-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 249 | |
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V7645SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 539 | |
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V7645IHC-7ML | Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only* | 7 ml | 539 |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2a, kappa |
| Clone Name | L26 |
| Purity | Protein G affinity chromatography |
| UniProt | P11836 |
| Localization | Predominantly cell surface with some cytoplasmic |
| Applications | Flow Cytometry : 1-2ug/10^6 cells Immunofluorescence : 1-2ug/ml Western Blot : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This CD20 antibody is available for research use only. |
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CD20 antibody detects CD20, a transmembrane phosphoprotein encoded by the MS4A1 gene. CD20 is expressed on the surface of nearly all mature B cells but is absent from early pro-B cells and fully differentiated plasma cells. By regulating calcium influx and B-cell receptor signaling, CD20 influences B-cell activation, proliferation, and differentiation. Because of its restricted expression and clinical relevance, CD20 antibody is widely used in immunology, oncology, and therapeutic development.
CD20 is a nonglycosylated protein of approximately 33â37 kDa with four transmembrane domains and both cytoplasmic and extracellular loops. It lacks a known natural ligand but plays a role in regulating B-cell receptor signaling and calcium mobilization. Its consistent expression during most stages of B-cell maturation has made it a hallmark of B-cell identification and classification.
The CD20 antibody clone L26 provides specific and reproducible recognition of this receptor. Clone L26 has been cited extensively in peer-reviewed studies and is a standard reagent in diagnostic pathology. It supports applications in immunohistochemistry, flow cytometry, and Western blotting, enabling reliable detection of B-cell populations in both normal and malignant samples.
Research using clone L26 has demonstrated how CD20 expression defines B-cell lineage in lymphomas and leukemias. Clinically, CD20 is a major therapeutic target for monoclonal antibody therapies in non-Hodgkinâs lymphoma and chronic lymphocytic leukemia. Detection with clone L26 provides a foundation for diagnosing these diseases and monitoring therapeutic responses. Beyond oncology, CD20 detection supports studies of autoimmune disease, vaccine responses, and B-cell biology.
NSJ Bioreagents provides this CD20 antibody to support oncology, immunology, and therapeutic research. Alternate names include MS4A1 antibody, B-lymphocyte surface antigen B1 antibody, pan-B-cell marker antibody, CD20 molecule antibody, and B-cell differentiation marker antibody.
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the CD20 antibody to be titered up or down for optimal performance.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Human tonsil B cells were used as the immunogen for this CD20 antibody.
CD20 antibody with azide can be stored at 2-8oC. The azide-free format should be aliquoted and stored at -20oC or colder.
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