- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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CD2 antibody recognizes CD2 molecule, a type I transmembrane glycoprotein encoded by the CD2 gene and commonly referred to as LFA-2 and T cell surface antigen CD2. CD2 is a member of the immunoglobulin superfamily and is expressed predominantly on the surface of T lymphocytes and natural killer cells. As an adhesion and co-stimulatory receptor, CD2 plays a central role in T cell activation, immune synapse formation, and intercellular communication within lymphoid tissues. CD2 antibody supports research applications focused on immune signaling, lymphoid architecture, and T cell lineage characterization.
Structurally, CD2 contains two extracellular immunoglobulin-like domains responsible for binding to CD58, its principal ligand on antigen-presenting cells and other immune cells. This ligand interaction strengthens T cell adhesion and enhances T cell receptor signaling, contributing to proliferation, cytokine secretion, and cytotoxic responses. The protein includes a single transmembrane domain and a cytoplasmic tail that participates in intracellular signaling cascades. CD2 is localized primarily to the plasma membrane, where it contributes to immune synapse organization and downstream activation pathways.
In normal human tissues, CD2 expression is restricted to thymocytes, peripheral T cells, and natural killer cells. Within lymph node, tonsil, and spleen, CD2 staining is typically observed in interfollicular and paracortical T cell zones, while germinal center B cells display minimal expression. This lineage-restricted distribution makes CD2 an important marker for identifying T cell populations in experimental systems. CD2 expression is also relevant in research involving T cell leukemias and lymphomas, where membranous localization assists in immunophenotypic profiling.
Clone LFA2/7106 has been evaluated using a comprehensive protein microarray containing thousands of full-length human proteins to assess binding specificity. Protein microarray validation supports selective target recognition and provides an additional layer of confidence in target engagement. CD2 antibody can be used to investigate T cell activation mechanisms, immune adhesion pathways, and lymphoid tissue organization in research settings. Its defined specificity and membrane-associated staining profile make it suitable for studies of T cell distribution and immune system biology.
Optimal dilution of the CD2 antibody should be determined by the researcher.
A recombinant fragment from the human protein was used as the immunogen for the CD2 antibody.
Aliquot the CD2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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