- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CD2 Antibody for IHC [clone LFA2/8681R] (V4641)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4641-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V4641-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V4641SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | LFA2/8681R |
| Purity | Protein A/G affinity |
| UniProt | P06729 |
| Localization | Cell surface |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This CD2 antibody is available for research use only. |
|
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CD2 antibody recognizes CD2 molecule, a type I transmembrane glycoprotein encoded by the CD2 gene and also known as LFA-2 and T cell surface antigen CD2. CD2 is a member of the immunoglobulin superfamily and is expressed predominantly on T lymphocytes and natural killer cells. As an adhesion and co-stimulatory receptor, CD2 plays a central role in T cell activation, immune synapse formation, and cell-cell communication within lymphoid tissues. This antibody is designed for research applications including immunohistochemical evaluation of T cell distribution in formalin-fixed tissue sections.
CD2 contains extracellular immunoglobulin-like domains that mediate interaction with CD58, its primary ligand on antigen-presenting cells and other immune cells. This interaction strengthens T cell adhesion and enhances T cell receptor signaling, contributing to proliferation, cytokine production, and cytotoxic function. The protein includes a single transmembrane domain and a cytoplasmic tail that participates in intracellular signaling cascades. CD2 localizes to the plasma membrane, where it organizes signaling complexes involved in adaptive immune responses.
In normal human tissues, CD2 expression is restricted to thymocytes, peripheral T cells, and natural killer cells. Within lymph node and tonsil, staining is typically observed in interfollicular T cell zones and paracortical regions, while germinal center B cells demonstrate minimal expression. This lineage-restricted pattern makes CD2 an important marker for identifying T cell populations in research applications. CD2 expression is also relevant in studies of T cell leukemias and lymphomas, where membranous localization supports immunophenotypic characterization of lymphoid malignancies.
Clone LFA2/8681R is a recombinant rabbit monoclonal antibody generated by defined sequence expression to promote lot-to-lot consistency and reproducible performance. CD2 antibody for IHC supports investigation of T cell biology, lymphoid tissue organization, and immune signaling pathways in research settings. Its defined specificity and membrane-associated staining profile make it suitable for studying T cell distribution in normal and disease-associated tissues.
Optimal dilution of the CD2 antibody should be determined by the researcher.
A recombinant fragment corresponding to the N-terminal of human CD2 protein was used as the immunogen for the CD2 antibody.
Aliquot the CD2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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