- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CD1A Antibody / Thymocyte Development Marker Antibody [clone C1A/8111R] (V4751)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4751-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V4751-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
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V4751SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | C1A/8111R |
| Purity | Protein A/G affinity |
| UniProt | P06126 |
| Localization | Cell surface |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This CD1A antibody is available for research use only. |
|
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CD1 molecule alpha 1 (CD1A) is a membrane glycoprotein encoded by the CD1A gene that functions in antigen presentation and is prominently expressed in cortical thymocytes during early stages of T-cell development. CD1A antibody, also referred to as CD1a antibody or T-cell surface glycoprotein CD1a antibody, enables detection of CD1A expression in studies of thymic biology and lymphocyte maturation. CD1A Antibody is particularly valuable for identifying developing T-cell populations and examining thymocyte differentiation within the thymus.
During thymic development, T-cell precursors undergo a series of maturation steps within the thymic cortex, where CD1a expression is strongly upregulated. This expression marks immature thymocytes undergoing selection processes that shape the developing T-cell repertoire. CD1A therefore serves as a useful marker for distinguishing early-stage thymocytes from more mature T cells found in the thymic medulla and peripheral lymphoid organs.
In histological analysis, CD1a-positive cells are observed in the thymic cortex with prominent membranous and cytoplasmic staining, reflecting high levels of expression during active stages of T-cell differentiation. This spatial distribution allows clear delineation of thymic architecture and supports analysis of developmental zones within the thymus. A CD1a antibody enables visualization of these patterns and facilitates study of thymocyte maturation within intact tissue sections.
Changes in thymocyte development are associated with immune system disorders, including immunodeficiency, autoimmune disease, and alterations in T-cell selection processes. Detection of CD1a can therefore be used to evaluate developmental abnormalities and to study factors that influence T-cell maturation and immune competence.
CD1A Antibody is therefore well suited for studies focused on thymocyte development and T-cell differentiation. Its use supports identification of immature T-cell populations and enables investigation of cellular processes that regulate thymic maturation, immune system development, and the formation of functional T-cell repertoires.
A full range of CD1A antibody reagents for immunohistochemistry, western blot, and flow cytometry is available on our CD1A Antibody collection page.
Optimal dilution of the CD1A Antibody / Thymocyte Development Marker Antibody should be determined by the researcher.
Recombinant full-length human CD1a protein was used as the immunogen for the CD1A Antibody / Thymocyte Development Marker Antibody.
Aliquot the CD1A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
CD1a antibody, thymocyte marker antibody, CD1A T-cell development antibody, cortical thymocyte marker antibody, T-cell surface glycoprotein CD1a antibody
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