- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CD19 Antibody for Rat (RQ7965)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ7965 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
|
| Availability | 1-3 business days |
| Species Reactivity | Rat |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity purified |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | F1LNH2 |
| Applications | Immunohistochemistry (FFPE) : 2-5ug/ml Direct ELISA : 0.1-0.5ug/ml |
| Limitations | This Cd19 antibody is available for research use only. |
|
Review this product on BioCompare and get a $20 Amazon gift card
|
Related Products
|
CD19 antibody recognizes CD19, a B cell-specific type I transmembrane glycoprotein that functions as a critical coreceptor in B cell receptor signaling. CD19 Antibody for Rat is developed to detect the rodent ortholog and recognizes rat Cd19 protein expressed on developing and mature B lymphocytes. CD19 is a member of the immunoglobulin superfamily and is localized to the plasma membrane, where it forms a signaling complex with CD21 and CD81 to amplify antigen receptor-mediated signaling. Through this complex, CD19 lowers the activation threshold of B cells and promotes downstream pathways involved in proliferation, differentiation, and survival.
The rat Cd19 gene encodes a protein containing two extracellular immunoglobulin-like domains, a single transmembrane region, and a cytoplasmic tail enriched in tyrosine residues that become phosphorylated following B cell activation. These phosphorylation events recruit signaling molecules such as PI3K, contributing to regulation of humoral immune responses. CD19 Antibody for Rat supports studies of normal B cell development in rat models, including investigations of bone marrow maturation, peripheral B cell maintenance, and antigen-driven activation.
In rat tissues, Cd19 expression is restricted to B lineage cells within bone marrow, spleen, lymph node, and other secondary lymphoid organs. Terminally differentiated plasma cells often exhibit reduced Cd19 expression, reflecting late-stage B cell maturation. Because of this lineage specificity, CD19 Antibody for Rat serves as a reliable marker for identifying B cells in immunologic and translational research using rat systems.
Altered Cd19 expression and B cell signaling dysregulation have been implicated in autoimmune disease models and experimental lymphoma studies in rodents. Accurate detection of rat Cd19 protein is therefore important for evaluating immune responses, studying B cell-driven pathology, and assessing therapeutic interventions in preclinical models. CD19 Antibody for Rat provides targeted recognition of the rat Cd19 antigen and facilitates analysis of B cell distribution and activation states.
By specifically recognizing rat Cd19 protein, this antibody offers a dependable reagent for researchers working with rat immune tissues and disease models. Its use enables detailed examination of B cell biology, immune regulation, and experimental immunotherapy approaches in rat-based studies.
Optimal dilution of the Cd19 antibody should be determined by the researcher.
E. coli-derived recombinant rat protein (amino acids D89-L420) was used as the immunogen for the Cd19 antibody.
After reconstitution, the Cd19 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz
