- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Related Products
|
CD19 antibody detects CD19, a transmembrane glycoprotein expressed throughout most stages of B-cell development. Encoded by the CD19 gene, this protein acts as a coreceptor with the B-cell receptor, amplifying antigen-driven signaling. Because CD19 is a pan-B-cell marker and is consistently expressed in hematologic malignancies, CD19 antibody is essential in immunology, hematology, and translational oncology research.
CD19 is a 95 kDa protein with extracellular immunoglobulin-like domains, a transmembrane region, and a cytoplasmic tail containing multiple tyrosine residues. Upon phosphorylation, these residues recruit kinases and adaptors that activate PI3K, AKT, and MAPK pathways. This lowers the threshold for B-cell activation, enhancing antibody production and immune responsiveness. Its role in signaling makes CD19 central to both normal immune defense and malignant transformation.
The CD19 antibody clone CD19/3117 delivers specific and reproducible detection. Clone CD19/3117 has been employed in peer-reviewed publications studying B-cell lineage identification, leukemia classification, and therapeutic targeting. Its consistent performance supports use in flow cytometry, immunohistochemistry, and functional assays measuring B-cell activation.
Research using clone CD19/3117 has highlighted how CD19 is not only a lineage marker but also a therapeutic target. Monoclonal antibodies and CAR T-cell therapies directed against CD19 have shown clinical success in B-cell malignancies, and detection with clone CD19/3117 provides an essential tool for evaluating patient samples and validating therapeutic interventions. In addition, CD19 studies have informed understanding of autoimmune disorders, where aberrant B-cell activity contributes to disease pathology.
NSJ Bioreagents supplies this CD19 antibody to support research in B-cell biology, leukemia, and targeted immunotherapy. Alternate designations include B-lymphocyte antigen CD19 antibody, pan-B-cell marker antibody, B-cell receptor coreceptor antibody, B-cell lineage differentiation marker antibody, and CD19 molecule antibody.
Optimal dilution of the CD19 antibody should be determined by the researcher.
A recombinant human partial protein (amino acids 96-281) was used as the immunogen for the CD19 antibody.
Store the CD19 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.