- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CD185 Antibody / CXCR5 / BLR1 / MDR15 [clone CXCR5/8279R] (V4214)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4214-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
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V4214-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V4214SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | CXCR5/8279R |
| Purity | Protein A/G affinity |
| UniProt | P32302 |
| Localization | Cell membrane |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT |
| Limitations | This CD185/CXCR5 antibody is available for research use only. |
|
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CD185 antibody, also known as CXCR5 antibody, recognizes C-X-C motif chemokine receptor 5, a seven-transmembrane G protein-coupled receptor encoded by the CXCR5 gene and commonly referred to as Burkitt lymphoma receptor 1. CD185 is primarily localized to the plasma membrane of B lymphocytes and subsets of T cells, particularly follicular helper T cells, where it regulates chemokine-directed migration. As a member of the CXC chemokine receptor family, CXCR5 binds the ligand CXCL13 and plays a central role in lymphoid follicle organization and germinal center formation.
CD185 antibody detects a multi-pass transmembrane receptor composed of seven alpha-helical membrane-spanning domains, extracellular regions responsible for ligand recognition, and intracellular domains that couple to heterotrimeric G proteins. Upon binding CXCL13, CXCR5 activates downstream signaling pathways that promote cytoskeletal rearrangement and directed chemotaxis. Through these mechanisms, CD185 directs B cells and T follicular helper cells into B cell follicles within secondary lymphoid tissues, supporting adaptive immune responses and antibody affinity maturation.
Functionally, CXCR5 is essential for humoral immunity and proper germinal center architecture. Expression of CD185 defines follicular B cells and T follicular helper cells and is widely used as a marker in immunophenotyping studies. Dysregulated CXCR5 signaling has been implicated in autoimmune disorders, chronic inflammatory diseases, and lymphoid malignancies. In certain B cell lymphomas, altered CD185 expression may influence tumor cell localization within lymphoid microenvironments.
The CXCR5 gene is located on chromosome 11 and is regulated during lymphocyte activation and differentiation. Because CD185 expression is largely restricted to defined immune cell subsets, detection of this receptor provides insight into lymphocyte trafficking, germinal center dynamics, and immune cell compartmentalization within tissues.
This recombinant monoclonal CD185 antibody (clone CXCR5/8279R) targets CXCR5 protein in research applications. CD185 antibody supports investigation of B cell biology, T follicular helper cell function, lymphoid tissue organization, and immune-mediated disease mechanisms.
Optimal dilution of the CD185/CXCR5 antibody should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the CD185/CXCR5 antibody.
Aliquot the CD185/CXCR5 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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