- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CD151 Antibody [clone 11G5a] (V8526)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V8526-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 539 | |
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V8526-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 249 | |
|
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V8526SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 539 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | 11G5a |
| Purity | Protein G affinity chromatography |
| UniProt | P48509 |
| Localization | Cell surface |
| Applications | Flow Cytometry : 1-2ug/million cells Immunofluorescence : 1-2ug/ml Western Blot : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT |
| Limitations | This CD151 antibody is available for research use only. |
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CD151 antibody detects CD151, a member of the tetraspanin family encoded by the CD151 gene. CD151 is a four-transmembrane domain protein that interacts with integrins and organizes membrane microdomains. It plays roles in adhesion, migration, angiogenesis, and metastasis. Because of its influence on tumor progression and vascular biology, CD151 antibody is widely used in oncology, immunology, and cell biology research.
CD151 associates with integrins such as α3β1, α6β1, and α6β4, regulating cell-extracellular matrix interactions. By clustering with integrins and signaling molecules, it enhances cell motility and contributes to invasion and metastasis in cancer. In vascular biology, CD151 promotes angiogenesis and endothelial stability, while in epithelial tissues, it supports polarity and barrier function. These diverse roles make CD151 a multifunctional regulator of cell communication.
The CD151 antibody clone 11G5a provides specific and reproducible recognition of this tetraspanin. Clone 11G5a has been referenced in peer-reviewed publications investigating carcinoma progression, endothelial biology, and integrin regulation. Its performance supports immunohistochemistry, flow cytometry, and studies of protein-protein interactions.
Research using clone 11G5a has shown how CD151 overexpression correlates with aggressive tumors, including prostate, breast, and lung cancer. In endothelial biology, it has been implicated in vascular remodeling and angiogenesis, processes critical to both normal development and disease. Studies employing this antibody have also clarified CD151âs role in immune cell migration and adhesion, demonstrating its broad biological significance.
NSJ Bioreagents provides this CD151 antibody to support oncology, vascular biology, and immunology research. Alternate names include tetraspanin 24 antibody, membrane glycoprotein SFA1 antibody, integrin-associated protein antibody, platelet endothelial tetraspanin antibody, and CD151 molecule antibody.
Optimal dilution of the CD151 antibody should be determined by the researcher.
Store the CD151 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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