- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CD137L Antibody / 4-1BBL / TNFSF9 [clone CD137L/1547] (V8184)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V8184-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 539 | |
|
|
V8184-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 249 | |
|
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V8184SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 539 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2a, kappa |
| Clone Name | CD137L/1547 |
| Purity | Protein G affinity chromatography |
| UniProt | P41273 |
| Localization | Cell surface, cytoplasmic |
| Applications | Flow Cytometry : 1-2ug/10^6 cells in 0.1ml Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This CD137L antibody is available for research use only. |
|
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CD137L antibody detects CD137 ligand, also known as TNFSF9, a member of the tumor necrosis factor superfamily. CD137 ligand is encoded by the TNFSF9 gene and is expressed on antigen-presenting cells, including B cells, macrophages, and dendritic cells. Interaction with its receptor CD137 (4-1BB) on T cells provides a costimulatory signal that enhances proliferation, survival, and cytokine production. Because of its role in immune regulation and therapeutic potential, CD137L antibody is important in immunology, cancer immunotherapy, and inflammation research.
CD137 ligand is a type II transmembrane protein with an intracellular tail, a transmembrane region, and a TNF homology domain that mediates receptor binding. Engagement of CD137 on T cells by CD137L amplifies T-cell receptor signaling, supporting expansion of effector T cells and promoting long-term memory responses. This costimulatory pathway enhances cytotoxic activity, making it a target for immunotherapy strategies aimed at boosting anti-tumor immunity.
The CD137L antibody clone CD137L/1547 provides specific and reproducible detection. Clone CD137L/1547 has been used in peer-reviewed studies investigating T-cell costimulation, immune checkpoint regulation, and tumor immunology. Its versatility supports use in flow cytometry, immunohistochemistry, and in vitro assays examining ligand expression and function.
Research using clone CD137L/1547 has clarified how CD137-CD137L interactions modulate immune responses in cancer, viral infection, and autoimmunity. In oncology, upregulation of this pathway promotes antitumor T-cell activity, while in autoimmunity, it can exacerbate inflammation. The antibody has also been applied in studies of therapeutic agonists targeting CD137 signaling, providing a framework for translational research into immune modulation.
NSJ Bioreagents provides this CD137L antibody to support immunology, cancer immunotherapy, and inflammation studies. Alternate designations include TNFSF9 antibody, 4-1BB ligand antibody, CD137 ligand antibody, tumor necrosis factor ligand superfamily member 9 antibody, and costimulatory molecule antibody.
Optimal dilution of the CD137L antibody should be determined by the researcher.
A recombinant full-length human CD137L protein was used as the immunogen for the CD137L antibody.
Store the CD137L antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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