- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CD137 Antigen Antibody CDLA137-1 / T Cell Antigen ILA Antibody [clone CDLA137-1] (V7531)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V7531-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V7531-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V7531SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 | |
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V7531IHC-7ML | Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only* | 7 ml | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | CDLA137-1 |
| Purity | Protein G affinity chromatography |
| UniProt | Q07011 |
| Localization | Cell surface, cytoplasmic |
| Applications | Immunofluorescence : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT Prediluted IHC Only Format : incubate for 30 min at RT (1) |
| Limitations | This CD137 Antigen Antibody CDLA137-1 / T Cell Antigen ILA Antibody is available for research use only. |
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CD137 Antigen Antibody CDLA137-1 recognizes CD137, an immune costimulatory receptor encoded by the TNFRSF9 gene and also widely known as 4-1BB. CD137 is a member of the tumor necrosis factor receptor superfamily and was historically identified as the T cell antigen ILA, or induced by lymphocyte activation. Expression of CD137 is generally low on resting lymphocytes but can increase substantially following cellular activation. The receptor is particularly associated with activated T cells and is also expressed by natural killer cells and other immune-cell populations.
CD137 interacts with its ligand TNFSF9, commonly known as CD137L or 4-1BBL. Ligand engagement promotes recruitment of TRAF-family signaling proteins to the cytoplasmic region of CD137 and activates downstream pathways that include NF-kappaB and MAPK signaling. These responses can support lymphocyte survival, proliferation, cytokine production, and effector activity. CD137-mediated costimulation therefore contributes to the expansion and persistence of activated immune-cell populations and the regulation of cellular immune responses.
CD137 is studied extensively in immunology, inflammation, and cancer research. Its activation-dependent expression makes the receptor useful for investigating activated lymphocyte populations, while its costimulatory activity has generated considerable interest in mechanisms that regulate antitumor immunity. T Cell Antigen ILA Antibody research can also provide a connection to earlier literature in which CD137 was described using the ILA designation before the CD137 and TNFRSF9 nomenclature became widely established.
Clone CDLA137-1 is a mouse monoclonal antibody generated against a recombinant fragment corresponding to amino acids 19-188 of human CD137. The defined monoclonal format provides a reagent for investigating CD137 expression and complements research examining TNFRSF9-mediated immune costimulation. NSJ Bioreagents supplies clone CDLA137-1 for research use only.
A CD137 Antigen Antibody can be used to investigate CD137 expression and its relationship to lymphocyte activation, immune costimulation, inflammatory responses, and antitumor immunity.
For a CD137 monoclonal with broader IF, FACS, IHC, Western blot, and protein microarray validation, see our CD137 Antibody 4-1BB/3201 / 4-1BB Antibody page.
Optimal dilution of the CD137 Antigen Antibody CDLA137-1 / T Cell Antigen ILA Antibody should be determined by the researcher.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
A recombinant human CD137 protein fragment within amino acids 19-188 was used as the immunogen for the CD137 Antigen Antibody CDLA137-1.
Store the CD137 Antigen Antibody CDLA137-1 at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
T cell antigen ILA antibody, ILA antibody, induced by lymphocyte activation antibody, 4-1BB antibody, TNFRSF9 antibody, CD137 antibody, CDw137 antibody
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